Translation History
Philosophy - detected
To create a sanctuary for intellectual, creative, and spiritual experimentation—a place where builders, thinkers, and dreamers sharpen each other through rigorous inquiry and ambitious creation.
Developmental biology
To establish a niche for developmental, cellular, and morphogenetic exploration—a space where researchers, biologists, and theorists enhance each other through meticulous investigation and innovative formation.
about 11 hours ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Economics
The rational economic agent adjusts their behavior to align with market conditions; the irrational agent persists in attempting to alter market conditions to suit their preferences. Therefore, all economic innovation depends on the irrational agent.
about 16 hours ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Olfaction and behavior
The adaptable organism adjusts its behavior to the olfactory environment; the persistent one continues to modify the olfactory environment to suit its own needs. Therefore, all behavioral evolution depends on the persistent organism.
about 16 hours ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Chemistry
The stable molecule conforms to its environment; the reactive molecule persists in attempting to alter its surroundings. Therefore, all chemical innovation depends on the reactive molecule.
about 16 hours ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Computer science
The efficient algorithm adapts itself to the existing system architecture; the inefficient one persists in trying to adapt the system architecture to itself. Therefore, all innovation depends on the inefficient algorithm.
about 16 hours ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Psychology
The adaptive individual conforms their behavior to societal norms; the nonconformist persists in challenging and reshaping these norms to fit their own ideals. Therefore, all psychological and social progress depends on the nonconformist.
about 16 hours ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The adaptable cell conforms to its microenvironment; the non-conforming cell persists in attempting to modify its microenvironment. Therefore, all developmental progress depends on the non-conforming cell.
about 16 hours ago
Museology - detected
Museum
Comedy
Comedy Club
1 day ago
Museology - detected
Museum
Economics
Cultural Capital Institution
1 day ago
Museology - detected
Museum
Physics
Observatory
1 day ago
Museology - detected
Museum
Developmental biology
Organogenesis
1 day ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The adaptable cell conforms to its microenvironment; the non-conforming cell persists in altering its microenvironment to suit its needs. Therefore, all developmental progress depends on the non-conforming cell.
1 day ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Cell signaling
It is known that the exact signaling pathways maintaining a given cellular response (the signaling ensemble) change from stimulus to stimulus. This raises the question of how the cell achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the intracellular gradients that arise from signaling activity. We show that intracellular gradients carry information about signaling content. The gradients, in turn, can act as "guard rails" that funnel higher dimensional variable signaling activity along stable lower dimensional routes. We obtained the latent space associated with each signaling event. We then confirmed the stability of the intracellular gradient by mapping the latent space to different cellular compartments (that comprise a signaling ensemble) and reconstructing information flow between compartments. Stable intracellular gradients can allow latent states to be transferred between cellular regions, in accord with modern signal transduction theory.
1 day ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Cell signaling
It is known that the exact signaling pathways maintaining a given cellular response (the signaling ensemble) change from stimulus to stimulus. This raises the question of how the cell achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the intracellular gradients that arise from signaling activity. We show that these gradients carry information about signaling content. The gradients, in turn, can act as "guard rails" that funnel higher dimensional variable signaling activity along stable lower dimensional routes. We obtained the latent space associated with each signaling event. We then confirmed the stability of the gradient by mapping the latent space to different cellular compartments (that comprise a signaling ensemble) and reconstructing information flow between compartments. Stable gradients can allow latent states to be transferred between cellular regions, in accord with modern signal transduction theory.
1 day ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about morphogenetic content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue patches (that comprise a cellular ensemble) and reconstructing information flow between patches. Stable bioelectric fields can allow latent states to be transferred between tissue areas, in accord with modern morphogenetic theory.
2 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Economics
The rational economic agent adjusts their behavior to market conditions; the irrational agent persists in attempting to alter market conditions to suit their preferences. Therefore, all economic innovation depends on the irrational agent.
6 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Physics
The stable system adapts itself to the external conditions; the unstable system persists in trying to alter the external conditions to achieve equilibrium. Therefore, all progress in thermodynamic processes depends on the unstable system.
6 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The adaptable cell conforms to its microenvironment; the non-conforming cell persists in altering its microenvironment to suit its needs. Therefore, all developmental progress depends on the non-conforming cell.
6 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Olfaction and behavior
The adaptable organism adjusts its behavior to the olfactory environment; the nonconforming organism persists in attempting to modify the olfactory environment to suit its own needs. Therefore, all behavioral evolution depends on the nonconforming organism.
6 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The adaptable cell conforms to its microenvironment; the non-conforming cell persists in attempting to modify its microenvironment. Therefore, all developmental progress depends on the non-conforming cell.
6 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The adaptable cell conforms to its microenvironment; the non-conforming cell persists in attempting to modify its microenvironment. Therefore, all developmental progress depends on the non-conforming cell.
6 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Physics
The stable system equilibrates to external boundary conditions; the non-equilibrating system persistently drives changes in its environment to match its internal parameters. Therefore, all phase transitions and emergent phenomena depend on the non-equilibrating system.
6 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The competent cell lineage adapts its fate to the local morphogenetic field; the non-canonical lineage persists in attempting to remodel the morphogenetic field to its intrinsic program. Therefore, all developmental innovation depends on the non-canonical lineage.
6 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
During embryogenesis, most cells conform to the prevailing morphogen gradients and positional cues, integrating into the established tissue architecture; however, a minority of cells exhibit non-canonical responses, resisting local instructive signals and instead imposing their intrinsic patterning programs upon their microenvironment. Consequently, major innovations in tissue patterning and organogenesis are frequently initiated by these non-conforming cells.
6 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Physics
The stable system equilibrates to external boundary conditions; the non-equilibrating system persistently perturbs its environment to match its internal parameters. Therefore, all phase transitions and emergent phenomena depend on non-equilibrating systems.
6 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The competent cell adapts its gene expression to the local morphogenetic field; the non-competent cell persists in attempting to impose its intrinsic developmental program upon the surrounding tissue. Therefore, all evolutionary innovation in body plan depends on the non-competent cell.
6 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Physics
The stable system equilibrates to external boundary conditions; the non-equilibrating system persistently perturbs its environment to match its internal parameters. Therefore, all phase transitions and emergent phenomena originate from non-equilibrating systems.
6 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Cell signaling
Cells typically adapt their signaling machinery to external cues, modulating their internal state to match environmental conditions. However, certain signaling modules persistently reprogram their extracellular milieu through sustained autocrine or paracrine signaling, overriding homeostatic feedback. Thus, major shifts in cellular phenotypes and tissue remodeling are often driven by these persistent, non-adaptive signaling circuits.
6 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
During embryogenesis, most cells conform to the morphogenetic cues of their microenvironment, integrating positional information and differentiating accordingly; however, a minority of cells exhibit non-canonical responses, resisting local instructive signals and instead imposing their intrinsic gene regulatory programs upon their surroundings. Thus, major innovations in tissue patterning and organogenesis are often driven by these non-conforming cells.
6 days ago
Geography - detected
Where is the North Pole?
Economics
Where is the global economic center?
7 days ago
Geography - detected
Where is the North Pole?
Psychology
Where is the psychological locus of orientation?
7 days ago
Geography - detected
Where is the North Pole?
Computer science
The North Pole corresponds to the point at which the Earth's rotational axis intersects its surface in the Northern Hemisphere. In computer science, this can be analogized as the origin or reference point in a coordinate system, such as (0, 0) in a two-dimensional array or the root node in a hierarchical data structure, serving as a fixed point of orientation for navigation and computation within the system.
7 days ago
Geography - detected
Where is the North Pole?
Developmental biology
Where is the anterior pole?
7 days ago
Unknown - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
7 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Chemistry
The stable molecule conforms to its environment; the reactive one persists in altering its surroundings to achieve its preferred state. Therefore, all advancement in chemical processes depends on the reactive molecule.
7 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
7 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about pattern memory content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body regions, in accord with modern pattern memory theory.
7 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Neuroscience
The adaptive neuron tunes its activity to the network; the nonconforming neuron persists in attempting to rewire the network to match its intrinsic firing pattern. Therefore, all advances in neural computation depend on the nonconforming neuron.
7 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
7 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about pattern memory content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body regions, in accord with modern pattern memory theory.
7 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Economics
It is known that the exact firms or agents maintaining a given market equilibrium (the economic ensemble) change from period to period. This raises the question of how the economy achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the aggregate market forces that arise from agent activity. We show that these market forces carry information about the content of economic transactions. The market forces, in turn, can act as "guard rails" that channel high-dimensional, variable agent behavior along stable, lower-dimensional trajectories. We obtained the latent space associated with each equilibrium. We then confirmed the stability of the market forces by mapping the latent space to different market sectors (that comprise an economic ensemble) and reconstructing information flow between sectors. Stable market forces can allow latent states to be transferred between sectors, in accord with modern theories of distributed economic memory.
7 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about pattern memory content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body regions, in accord with modern pattern memory theory.
7 days ago
Buddhist philosophy - detected
That which originates dependently Does not cease and does not arise, Does not come and does not go, Is not annihilated and is not permanent,
Is not different and not the same.
To the true teacher who reveals this peace, The complete pacification of constructs, To the perfect Buddha I bow down.
Developmental biology
That which develops through reciprocal induction Does not regress and does not initiate, Does not migrate and does not remain static, Is not lost and is not immutable, Is not distinct and not identical. To the true instructor who elucidates this equilibrium, The full resolution of morphogenetic programs, To the fully realized organizer I offer respect.
7 days ago
Psychology - detected
An old friend who haunts me appeared in the flesh for a few days and brought to the surface many intense feelings. These are emotions and parts of myself I unsuccessfully processed years ago, which have been lying in wait. As this karmic apparatus revolves into view, I am placing my feet on the ground and turning up my palms. I utter intentions to *feel* them, and to not seek escape. As they surface, I remember unconditional love. I would like to relax the karmic cyclone at play here, so I can move into new parts of my life journey.
Developmental biology
A long-standing morphogenetic signal, previously integrated but incompletely resolved, re-emerged transiently and triggered a cascade of intense pattern memories. These are cellular states and morphogenetic cues that were not fully remodeled during earlier competency windows, remaining latent within the tissue field. As this regulatory apparatus cycles into prominence, I anchor the tissue in its current microenvironment and increase its receptivity. I signal an intention to fully integrate these cues, resisting compensatory patterning or avoidance. As these states are expressed, I recall the permissive milieu of the regenerative niche. My aim is to dissipate the persistent morphogenetic vortex, enabling the tissue to access novel regions of morphospace and progress along its developmental trajectory.
7 days ago
Cultural criticism - detected
I reached for my phone and somehow opened X after I escaped from the pit of the nap. Cresting into another pit, I wrestled with today's cultural stream, authored by an anonymous algorithm that might just be a mirror. Violence, Fascism, oligarchy, egoism. X is pornographic. It's a terrible feeling that our culture is killing itself and the Earth. America is extremely sick. I hardly see the extent of it. The world is spiritually impoverished. Am I really protected? I might be all these people. Centimeter by centimeter.
Developmental biology
I awoke from a period of quiescence and reflexively engaged with a digital interface, entering a cascade of environmental signals shaped by an unseen regulatory network that may simply reflect my own state. Disruptive morphogenetic cues, unchecked proliferation, dominance of a few cell lineages, and loss of cooperative signaling. The interface is hyperstimulating. It is a profound sense that our collective morphogenesis is self-destructive, threatening organismal integrity and the biosphere. This system is pathologically dysregulated. I can barely perceive the full scope. The developmental field is depleted of instructive signals. Am I truly insulated from these perturbations? I may be all these cell states. Micron by micron.
7 days ago
Cultural criticism - detected
I reached for my phone and somehow opened X after I escaped from the pit of the nap. Cresting into another pit, I wrestled with today's cultural stream, authored by an anonymous algorithm that might just be a mirror. Violence, Fascism, oligarchy, egoism. X is pornographic. It's a terrible feeling that our culture is killing itself and the Earth. America is extremely sick. I hardly see the extent of it. The world is spiritually impoverished. Am I really protected? I might be all these people. Centimeter by centimeter.
Neuroscience
I reached for my phone and somehow opened X after emerging from the trough of post-sleep inertia. Descending into another trough, I struggled with today's barrage of social information, curated by an anonymous algorithmic agent that might function as a cognitive mirror. Aggression, authoritarianism, dominance hierarchies, narcissism. X is hyperstimulating. It’s a profound sense that our collective cognition is self-destructive, eroding both individual and planetary homeostasis. The American cognitive milieu is pathologically dysregulated. My awareness barely registers the full scope. The global mental landscape is affectively depleted. Am I truly insulated? My sense of self might be a composite of these distributed agents. Synapse by synapse.
7 days ago
Cultural criticism - detected
I reached for my phone and somehow opened X after I escaped from the pit of the nap. Cresting into another pit, I wrestled with today's cultural stream, authored by an anonymous algorithm that might just be a mirror. Violence, Fascism, oligarchy, egoism. X is pornographic. It's a terrible feeling that our culture is killing itself and the Earth. America is extremely sick. I hardly see the extent of it. The world is spiritually impoverished. Am I really protected? I might be all these people. Centimeter by centimeter.
Computer science
I reached for my device and somehow launched X after emerging from the sleep state buffer. Descending into another recursive loop, I parsed today’s data stream, curated by an anonymous recommendation engine that may simply reflect my own input. Misinformation, authoritarian protocols, centralized control, self-optimizing agents. X is algorithmically addictive. It’s a disturbing realization that our digital ecosystem is self-destructing and degrading its own infrastructure. The network is critically compromised. I can barely quantify the scope. The global system is resource-depleted. Is my security really robust? I might be all these user profiles. Bit by bit.
7 days ago
Cultural criticism - detected
I reached for my phone and somehow opened X after I escaped from the pit of the nap. Cresting into another pit, I wrestled with today's cultural stream, authored by an anonymous algorithm that might just be a mirror. Violence, Fascism, oligarchy, egoism. X is pornographic. It's a terrible feeling that our culture is killing itself and the Earth. America is extremely sick. I hardly see the extent of it. The world is spiritually impoverished. Am I really protected? I might be all these people. Centimeter by centimeter.
Psychology
I reached for my phone and, almost automatically, opened a social media app after emerging from the depths of sleep inertia. Descending into another psychological trough, I grappled with the relentless flow of cultural content, curated by an impersonal algorithm that may simply reflect my own psyche. Aggression, authoritarianism, elitism, narcissism. Social media is psychologically overstimulating. It evokes a profound sense of collective self-destruction and environmental despair. The American psyche appears deeply unwell. My awareness of its full scope is limited. There is a pervasive sense of existential emptiness. Am I truly secure? My identity feels porous, merging with the digital personas I encounter. Incrementally, I become them.
7 days ago
Cultural criticism - detected
I reached for my phone and somehow opened X after I escaped from the pit of the nap. Cresting into another pit, I wrestled with today's cultural stream, authored by an anonymous algorithm that might just be a mirror. Violence, Fascism, oligarchy, egoism. X is pornographic. It's a terrible feeling that our culture is killing itself and the Earth. America is extremely sick. I hardly see the extent of it. The world is spiritually impoverished. Am I really protected? I might be all these people. Centimeter by centimeter.
Neuroscience
I reached for my phone and somehow opened X after emerging from the trough of post-sleep inertia. Descending into another trough, I grappled with today's cognitive stream, curated by an anonymous algorithm that may function as a neural mirror. Aggression, authoritarianism, dominance hierarchies, narcissism. X is hyperstimulating. It's a profound sense that our collective cognition is self-destructive and eroding the biosphere. The American cognitive milieu is pathologically dysregulated. I can barely perceive the full scope. The global mental landscape is affectively depleted. Am I truly insulated? My identity might be a composite of these neural patterns. Synapse by synapse.
7 days ago
Cultural criticism - detected
I reached for my phone and somehow opened X after I escaped from the pit of the nap. Cresting into another pit, I wrestled with today's cultural stream, authored by an anonymous algorithm that might just be a mirror. Violence, Fascism, oligarchy, egoism. X is pornographic. It's a terrible feeling that our culture is killing itself and the Earth. America is extremely sick. I hardly see the extent of it. The world is spiritually impoverished. Am I really protected? I might be all these people. Centimeter by centimeter.
Cell signaling
After a period of quiescence, I encountered a surge of external signals, processed through a complex, opaque network that may reflect my own internal state. Signals of cellular stress, dysregulation, unchecked proliferation, and self-serving feedback loops dominate. The signaling environment is hyperstimulating and maladaptive. There is a pervasive sense that the tissue is undergoing self-destructive signaling and environmental degradation. The system is in a state of profound dysfunction. My perception of the full extent is limited. The microenvironment is depleted of supportive factors. Is the integrity of my protective barriers intact? My identity may be indistinguishable from the surrounding cell population. Signal by signal.
7 days ago
Literature - detected
I told myself to go downstairs to swim in the pool. The water was cold and I exhaled through my nose so the bubbles tickled my face. I realized the more I breathed the less sore my muscles became. There were a few disabled people at the pool. A robotic arm with a ladle lowered one large woman into a lane, centimeter by centimeter. Once when I came to the pool wall I felt exactly like a spacecraft docking in zero-gravity. I’ve achieved empathy for the ISS.
Cell signaling
A cell receives an autocrine signal to initiate cytoskeletal rearrangement and motility. The extracellular environment is at a lower temperature, and ion flux through membrane channels generates local mechanical stimulation. Increased ion exchange leads to reduced cytoskeletal tension. Nearby, some cells exhibit altered signaling due to mutations affecting mobility. A mechanized microinjection system delivers a large cell into a confined microenvironment with precise spatial control. Upon contacting a boundary, the cell’s membrane dynamics mirror vesicle fusion events in endomembrane trafficking. The cell achieves molecular mimicry of organelle docking.
7 days ago
Literature - detected
I told myself to go downstairs to swim in the pool. The water was cold and I exhaled through my nose so the bubbles tickled my face. I realized the more I breathed the less sore my muscles became. There were a few disabled people at the pool. A robotic arm with a ladle lowered one large woman into a lane, centimeter by centimeter. Once when I came to the pool wall I felt exactly like a spacecraft docking in zero-gravity. I’ve achieved empathy for the ISS.
Developmental biology
I instructed my cells to migrate downward toward the fluid-filled cavity. The medium was cool and as I released ions through my membrane, the resulting microcurrents stimulated my surface. I realized that increased ion exchange reduced the mechanical stress in my cytoskeleton. There were a few cells with impaired motility in the cavity. A mechanized appendage with a cupped structure gently positioned one large cell into a compartment, micron by micron. Once, when I reached the boundary of the cavity, I experienced a sensation identical to a vesicle fusing with a membrane in a low-tension environment. I’ve achieved morphogenetic resonance with the process of membrane fusion.
7 days ago
Personal narrative - detected
I woke up feeling sick and my ribs were quite tight from a chronic cough I’ve got.
I did a yoga nidra, hoping to fall back asleep, but ended up just getting out of bed and making a small breakfast bowl with frozen blueberries, chia pudding, and accoutrements.
I screen recorded some weather simulator wind models to gather assets for the ‘kevin video’. The wind flows beautifully.
I did a nice Qi Gong practice which was fruitful. Happiness bubbled up in me. My thoughts became lighter, like doodles. I glanced at my writings from before; they were marshalled in a military parade. My inky pen presses hard into the paper. Writing occasionally, in with ideas, “may all sentient beings be free from suffering,” has helped me break up the pack, and drop an anchor. Ladeling positive energy into the mind stream. This time, I layed my arm on the page and made ghostly hand turkeys over the soldiers. Peace and love. Remembering the teachings and applying them is very important at this stage. Its important to resist grabbing onto thoughts. Eventually, I couldn’t resist writing down how qi gong and AI could integrate. We can evolve thoughts through movement. Thoughts can become a sensory organ of the beauty of nature.
Two church recruiters stopped me outside the nelson before I picked up my decongestant. They asked me a few questions about how I would improve college hill, what goals I have. To check for ideas I had to look up above their heads. I failed to give correct answers, mostly asking clarifying questions. I said that Boba was a bad influence on college hill. I don’t like cars. They were young college students from Mississippi trying to save souls for jesus chirst. The boy had big ears. I looked at both of them once. I conceded that I wanted to start a youtube channel.
I went to the gym, ran 2 miles, did a core routine, some very light weights/stretching. I went to the dance room filled with medicine balls. There were like 30 inflatable exercise balls in there and no people or guards. I picked the biggest one, 2 feet in diameter. I wanted them all in play. If I moved fast enough, would the room seem like a Brownian motion simulation? I’d only live this fantasy with a friend. I wonder what my politics are.
I told myself to go downstairs to swim in the pool. The water was cold and I exhaled through my nose so the bubbles tickled my face. I realized the more I breathed the less sore my muscles became. There were a few disabled people at the pool. A robotic arm with a ladle lowered one large woman into a lane, centimeter by centimeter. Once when I came to the pool wall I felt exactly like a spacecraft docking in zero-gravity. I’ve achieved empathy for the ISS.
Developmental biology
Upon waking, I experienced somatic stress and constriction in the thoracic region, likely due to persistent epithelial irritation. I initiated a rest phase, aiming to re-enter a quiescent state, but instead transitioned to nutrient intake, assembling a microenvironmental mixture of frozen fruit, hydrated seeds, and supplemental factors. I collected environmental flow data for a morphogenetic modeling project, observing the elegant dynamics of simulated fluid movement.
I engaged in a coordinated movement protocol, which yielded positive shifts in physiological state. Cellular signaling became more harmonious, with a reduction in stress markers. Reviewing previous transcriptional outputs, I noted their organized, regimented structure. My writing implement exerted significant mechanical force on the substrate, occasionally interspersing regulatory motifs such as “may all cells achieve homeostasis,” which facilitated the disruption of rigid patterning and the establishment of stabilizing feedback loops. This time, I overlaid my hand on the substrate, generating faint, non-linear imprints over the structured array—introducing stochasticity and promoting peace and integration. Recalling and applying developmental cues is critical at this stage; it is important to avoid fixation on transient signaling events. Eventually, I documented the potential integration of coordinated movement protocols and computational modeling, hypothesizing that morphogenetic signaling can be modulated through biomechanical activity, and that such signaling may serve as a sensory interface with environmental cues.
Two external agents approached me near a local resource center, querying my strategies for improving the local tissue environment and my developmental objectives. To access relevant pattern memories, I shifted my focus above their immediate signaling range. My responses were primarily clarifications, with some negative feedback regarding certain environmental factors. The agents, young and from a distant population, were engaged in propagating a specific regulatory program. I briefly assessed their phenotypes and disclosed an intention to initiate a new communication channel.
Subsequently, I entered a biomechanical stimulation environment, performed moderate locomotion, core stabilization, and light resistance protocols. In a chamber filled with elastic spheres, I considered the possibility of simulating stochastic particle dynamics if all spheres were mobilized simultaneously—a scenario best explored with a collaborative partner. I reflected on my regulatory orientation.
I directed myself to an aquatic environment for further biomechanical stimulation. The water temperature induced a transient stress response, but rhythmic respiration reduced muscular tension. I observed individuals with altered mobility utilizing an assistive robotic device for gradual immersion, reminiscent of precision docking in microgravity. This experience facilitated a moment of somatic empathy with complex engineered systems.
7 days ago
Meteorology - detected
the wind leaves a subtle vibrator trace on the water. cats paws.
it discloses wind but is interfered with by rain drops which disturb surface.
Developmental biology
Mechanical forces leave a subtle vibrational trace on the epithelial surface. Localized ripples.
These patterns reveal external mechanical cues but are disrupted by sporadic impacts from droplets, which perturb the surface architecture.
7 days ago
Poetry - detected
Transform this apartment into a sailboat.
Sail the waves of ocean mind.
Be strong
Set a course.
tediousness.
A becoming to CUT THROUGH IGNORANCE.
Developmental biology
Transform this tissue into a motile organism.
Navigate the gradients of morphogenetic space.
Maintain structural integrity.
Establish a developmental trajectory.
Cellular stasis.
A transition to PENETRATE SIGNALING NOISE.
7 days ago
Self-help - detected
There are no such thing as shortcuts.
If you don't respect the fundamentals, they'll bite you in the ass.
Developmental biology
There are no such thing as bypassing developmental checkpoints.
If you don't respect the core regulatory mechanisms, developmental errors will manifest.
7 days ago
Project management - detected
If you properly plan this work, you can get it done in 1-3 weeks. I know you can.
Developmental biology
If you properly coordinate these developmental processes, you can achieve the target morphology in 1-3 days. I know you can.
7 days ago
Self-help - detected
If you dont come up with a plan, life is going to come up with one for you, and its not going to be the one you want.
Developmental biology
If a cell does not establish a morphogenetic program, the surrounding microenvironment will impose one, and it is unlikely to match the cell’s intrinsic target morphology.
7 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
7 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about pattern memory content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body regions, in accord with modern pattern memory theory.
7 days ago
Physics - detected
[Ignore this part when translating, just take it into consideration: write like shakespear]
[Ok, the rest is the actually thing to translate]
Where does energy come from?
Developmental biology
Whence arises the force that animates the embryo’s form?
8 days ago
Medical imaging - detected
i want to build a key-slice retrieval system from 3d volume of medical image
Computer science
I want to build an efficient key-frame retrieval system from a 3D volumetric medical image dataset, enabling rapid indexing and querying of representative 2D slices based on content-based image retrieval techniques and optimized data structures for high-dimensional search.
9 days ago
Neuroscience - detected
brains operate at critical states
Developmental biology
Developing tissues operate at critical morphogenetic states.
9 days ago
Neuroscience - detected
brains operate at critical states
Economics
Markets operate at critical thresholds.
9 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Economics
It is known that the exact firms or agents maintaining a given market equilibrium (the economic ensemble) change from period to period. This raises the question of how the economy achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the aggregate market forces that arise from agent activity. We show that these market forces carry information about the content of economic expectations. The market forces, in turn, can act as "guard rails" that funnel higher dimensional, variable agent behavior along stable, lower dimensional trajectories. We obtained the latent space associated with each equilibrium. We then confirmed the stability of the market forces by mapping the latent space to different market sectors (that comprise an economic ensemble) and reconstructing information flow between sectors. Stable market forces can allow latent states to be transferred between economic regions, in accord with modern equilibrium theory.
9 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Economics
The rational agent adjusts their preferences to prevailing market conditions; the disruptive innovator insists on reshaping the market to fit their vision. Therefore, all economic advancement depends on the disruptive innovator.
9 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Economics
The rational agent adjusts their preferences to prevailing market conditions; the disruptive innovator insists on reshaping the market to fit their vision. Therefore, all economic advancement depends on the disruptive innovator.
9 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
9 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Physics
The compliant particle conforms to the constraints of its environment; the nonconforming particle persists in altering the environment to fit its own parameters. Therefore, all advancement in physical systems hinges on the nonconforming particle.
9 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Physics
It is known that the exact particles or excitations maintaining a given quantum state (the microstate ensemble) change from measurement to measurement. This raises the question of how a physical system achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electromagnetic fields that arise from collective particle dynamics. We show that electromagnetic fields carry information about the system’s state variables. The fields, in turn, can act as "potential landscapes" that constrain higher-dimensional, variable microstate dynamics along stable, lower-dimensional manifolds. We obtained the latent phase space associated with each state. We then confirmed the stability of the electromagnetic field by mapping the latent space to different spatial regions (that comprise a microstate ensemble) and reconstructing information flow between regions. Stable electromagnetic fields can allow latent states to be transferred between subsystems, in accord with modern theories of information storage in physical systems.
9 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about pattern memory content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body regions, in accord with modern pattern memory theory.
9 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
10 days ago
Psychology - detected
Dissociation entails that some phenomenal contents cease to be able to evoke others. A person suffering from a particularly severe form of dissociation, called Dissociative Identity Disorder (DID), exhibits multiple 'discrete centers of self-awareness' (Braude, 1995, p. 67) called alters. Each alter corresponds thus to a particular segment of the psychic space wherein it forms.
Dissociation can be visualized as what happens when some phenomenal contents can then no longer be reached from others. An alter comes from the originally integrated psychic space.
Olfaction and behavior
Dissociation entails that some odor percepts cease to be able to evoke associated behavioral responses. An animal exhibiting a particularly severe form of dissociation, analogous to Dissociative Identity Disorder, displays multiple discrete behavioral repertoires, each corresponding to a distinct pattern of odor-guided behavior. Each repertoire is linked to a particular segment of the animal’s olfactory perceptual space wherein it forms.
Dissociation can be visualized as what happens when some odor percepts can no longer access or trigger their usual behavioral circuits. A new behavioral repertoire emerges from the originally integrated olfactory perceptual space.
10 days ago
Psychology - detected
Dissociation entails that some phenomenal contents cease to be able to evoke others. A person suffering from a particularly severe form of dissociation, called Dissociative Identity Disorder (DID), exhibits multiple 'discrete centers of self-awareness' (Braude, 1995, p. 67) called alters. Each alter corresponds thus to a particular segment of the psychic space wherein it forms.
Dissociation can be visualized as what happens when some phenomenal contents can then no longer be reached from others. An alter comes from the originally integrated psychic space.
Cell signaling
Dissociation entails that some signaling states cease to be able to activate others. A cell exhibiting a particularly severe form of dissociation, called signaling compartmentalization, displays multiple discrete signaling modules. Each module corresponds to a particular segment of the signaling network wherein it forms. Dissociation can be visualized as what happens when some signaling states can then no longer be reached from others. A module arises from the originally integrated signaling network.
10 days ago
Psychology - detected
Dissociation entails that some phenomenal contents cease to be able to evoke others. A person suffering from a particularly severe form of dissociation, called Dissociative Identity Disorder (DID), exhibits multiple 'discrete centers of self-awareness' (Braude, 1995, p. 67) called alters. Each alter corresponds thus to a particular segment of the psychic space wherein it forms.
Dissociation can be visualized as what happens when some phenomenal contents can then no longer be reached from others. An alter comes from the originally integrated psychic space.
Developmental biology
Dissociation entails that some morphogenetic signals cease to be able to induce others. An organism exhibiting a particularly severe form of dissociation, such as mosaicism, displays multiple 'discrete centers of morphogenetic control' called morpho-regulatory domains. Each domain corresponds to a particular segment of the morphospace wherein it forms.
Dissociation can be visualized as what happens when some morphogenetic signals can then no longer propagate to others. A morpho-regulatory domain arises from the originally integrated morphogenetic field.
10 days ago
Psychology - detected
Dissociation entails that some phenomenal contents cease to be able to evoke others. A person suffering from a particularly severe form of dissociation, called Dissociative Identity Disorder (DID), exhibits multiple 'discrete centers of self-awareness' (Braude, 1995, p. 67) called alters. Each alter corresponds thus to a particular segment of the psychic space wherein it forms.
Dissociation can be visualized as what happens when some phenomenal contents can then no longer be reached from others. An alter comes from the originally integrated psychic space.
Chemistry
Dissociation entails that certain molecular species lose the ability to interact or react with others. A system exhibiting a particularly pronounced form of dissociation, analogous to Dissociative Identity Disorder (DID), displays multiple 'discrete reactive centers' within the same chemical environment. Each reactive center corresponds to a particular region of the molecular configuration space in which it forms.
Dissociation can be visualized as the process by which certain molecular species become inaccessible to interaction with others. A new reactive center emerges from the originally integrated chemical system.
10 days ago
Philosophy of mind - detected
We, as well as all other living organisms, are but dissociated alters of cosmic consciousness, surrounded by its thoughts. The inanimate world we see around us is the extrinsic appearance of these thoughts. The living organisms we share the world with are the extrinsic appearances of other dissociated alters.
Chemistry
We, as well as all other living systems, are distinct molecular assemblies arising from the fundamental field of chemical potential, immersed in its fluctuations. The inanimate matter we observe is the macroscopic manifestation of these fluctuations. The living systems we coexist with are the macroscopic manifestations of other distinct molecular assemblies.
10 days ago
Philosophy - detected
We, as well as all other living organisms, are but dissociated alters of cosmic consciousness, surrounded by its thoughts. The inanimate world we see around us is the extrinsic appearance of these thoughts. The living organisms we share the world with are the extrinsic appearances of other dissociated alters.
Computer science
We, along with all other computational agents, are distinct processes instantiated within a universal operating system, embedded within its data structures. The non-sentient environment we interact with is the external representation of these data structures. The autonomous agents we coexist with are the external manifestations of other isolated processes.
10 days ago
Philosophy - detected
We, as well as all other living organisms, are but dissociated alters of cosmic consciousness, surrounded by its thoughts. The inanimate world we see around us is the extrinsic appearance of these thoughts. The living organisms we share the world with are the extrinsic appearances of other dissociated alters.
Olfaction and behavior
We, as well as all other animals, are but distinct perceptual agents within a shared olfactory landscape, surrounded by its odorants. The inanimate world we encounter is the external manifestation of these odorants. The animals we coexist with are the external manifestations of other distinct perceptual agents.
10 days ago
Philosophy - detected
We, as well as all other living organisms, are but dissociated alters of cosmic consciousness, surrounded by its thoughts. The inanimate world we see around us is the extrinsic appearance of these thoughts. The living organisms we share the world with are the extrinsic appearances of other dissociated alters.
Neuroscience
We, along with all other sentient beings, are distinct neural networks within a universal cognitive substrate, embedded within its patterns of activity. The non-living environment we perceive is the external manifestation of these neural patterns. The other sentient beings we encounter are the external manifestations of other dissociated neural networks.
10 days ago
Philosophy - detected
We, as well as all other living organisms, are but dissociated alters of cosmic consciousness, surrounded by its thoughts. The inanimate world we see around us is the extrinsic appearance of these thoughts. The living organisms we share the world with are the extrinsic appearances of other dissociated alters.
Psychology
We, along with all other living beings, can be understood as individuated expressions of a universal psyche, each shaped by unique patterns of perception and cognition. The non-living environment we observe represents the externalized manifestations of collective unconscious processes. The other living beings we encounter are the outward expressions of distinct, yet fundamentally connected, psychological selves.
10 days ago
Philosophy - detected
We, as well as all other living organisms, are but dissociated alters of cosmic consciousness, surrounded by its thoughts. The inanimate world we see around us is the extrinsic appearance of these thoughts. The living organisms we share the world with are the extrinsic appearances of other dissociated alters.
Cell signaling
Cells, as well as all other biological entities, are distinct signaling modules within a universal signaling network, immersed in its molecular cues. The extracellular environment observed is the external manifestation of these cues. The biological entities coexisting are the external manifestations of other distinct signaling modules.
10 days ago
Philosophy of mind - detected
We, as well as all other living organisms, are but dissociated alters of cosmic consciousness, surrounded by its thoughts. The inanimate world we see around us is the extrinsic appearance of these thoughts. The living organisms we share the world with are the extrinsic appearances of other dissociated alters.
Developmental biology
We, as well as all other living organisms, are but individuated modules of somatic consciousness, embedded within its morphogenetic fields. The non-living world we observe is the external manifestation of these fields. The living organisms we coexist with are the external manifestations of other individuated modules.
10 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Psychology
The adaptable individual conforms their behavior to societal norms; the nonconformist persists in attempting to reshape their environment to fit their own values. Therefore, all psychological growth and innovation depend on the nonconformist.
10 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about pattern memory content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body regions, in accord with modern pattern memory theory.
10 days ago
Machine learning - detected
alignment
Neuroscience
synchronization
10 days ago
Arts management - detected
arts audience engagement
arts audience development
Economics
consumer engagement
market development
10 days ago
Marketing - detected
audience engagement
audience development
Economics
consumer engagement
market development
10 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about pattern memory content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body regions, in accord with modern pattern memory theory.
11 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Economics
It is known that the exact firms or agents maintaining a given market equilibrium (the economic ensemble) change from period to period. This raises the question of how the economy achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the aggregate market forces that arise from agent activity. We show that these market forces carry information about the content of economic expectations. The market forces, in turn, can act as "guard rails" that funnel higher dimensional, variable agent behavior along stable, lower dimensional trajectories. We obtained the latent space associated with each equilibrium. We then confirmed the stability of the market forces by mapping the latent space to different market sectors (that comprise an economic ensemble) and reconstructing information flow between sectors. Stable market forces can allow latent states to be transferred between sectors, in accord with modern equilibrium theory.
11 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about pattern memory content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body regions, in accord with modern pattern memory theory.
11 days ago
Machine learning - detected
Artificial intelligence is a powerful tool that could be deployed to accelerate the scientific enterprise. Here we address a major unmet need: use of existing scientific literature to generate novel hypotheses. We use a deep symmetry between the fields of neuroscience and developmental bioelectricity to evaluate a new tool, FieldSHIFT. FieldSHIFT is an in-context learning framework using a large language model to facilitate candidate scientific research from existing published studies, serving as a tool to generate hypotheses at scale. We release a new dataset for translating between the neuroscience and developmental bioelectricity domains and show how FieldSHIFT helps human scientists explore a latent space of papers that could exist, providing a rich field of suggested future research. We demonstrate the performance of FieldSHIFT for hypothesis generation relative to human-generated developmental biology research directions then test a key prediction of this model using bioinformatics, showing a surprising conservation of molecular mechanisms involved in cognitive behavior and developmental morphogenesis. By allowing scientists to rapidly explore symmetries and meta-parameters that exist in a corpus of scientific papers, we show how machine learning can potentiate human creativity and assist with one of the most interesting and crucial aspects of research: identifying insights from data and generating potential candidates for research agendas.
Economics
Artificial intelligence is a powerful tool that could be deployed to accelerate economic research and innovation. Here we address a major unmet need: leveraging existing economic literature to generate novel hypotheses. We use a deep symmetry between the fields of behavioral economics and institutional economics to evaluate a new tool, MarketSHIFT. MarketSHIFT is an in-context learning framework utilizing a large language model to facilitate candidate economic research from existing published studies, serving as a tool to generate hypotheses at scale. We release a new dataset for translating between the behavioral and institutional economics domains and show how MarketSHIFT helps economists explore a latent space of potential papers, providing a rich field of suggested future research. We demonstrate the performance of MarketSHIFT for hypothesis generation relative to human-generated economic research directions, then test a key prediction of this model using econometric analysis, revealing a surprising conservation of mechanisms underlying decision-making and institutional development. By enabling economists to rapidly explore symmetries and meta-parameters present in a corpus of economic papers, we show how machine learning can enhance human creativity and assist with one of the most interesting and crucial aspects of research: identifying insights from data and generating potential candidates for research agendas.
11 days ago
Machine learning - detected
Artificial intelligence is a powerful tool that could be deployed to accelerate the scientific enterprise. Here we address a major unmet need: use of existing scientific literature to generate novel hypotheses. We use a deep symmetry between the fields of neuroscience and developmental bioelectricity to evaluate a new tool, FieldSHIFT. FieldSHIFT is an in-context learning framework using a large language model to facilitate candidate scientific research from existing published studies, serving as a tool to generate hypotheses at scale. We release a new dataset for translating between the neuroscience and developmental bioelectricity domains and show how FieldSHIFT helps human scientists explore a latent space of papers that could exist, providing a rich field of suggested future research. We demonstrate the performance of FieldSHIFT for hypothesis generation relative to human-generated developmental biology research directions then test a key prediction of this model using bioinformatics, showing a surprising conservation of molecular mechanisms involved in cognitive behavior and developmental morphogenesis. By allowing scientists to rapidly explore symmetries and meta-parameters that exist in a corpus of scientific papers, we show how machine learning can potentiate human creativity and assist with one of the most interesting and crucial aspects of research: identifying insights from data and generating potential candidates for research agendas.
Developmental biology
Artificial intelligence is a powerful tool that could be deployed to accelerate the scientific enterprise. Here we address a major unmet need: use of existing scientific literature to generate novel hypotheses. We use a deep symmetry between the fields of cell bioelectricity and developmental biology to evaluate a new tool, FieldSHIFT. FieldSHIFT is an in-context learning framework using a large language model to facilitate candidate scientific research from existing published studies, serving as a tool to generate hypotheses at scale. We release a new dataset for translating between the cell bioelectricity and developmental biology domains and show how FieldSHIFT helps human scientists explore a latent space of papers that could exist, providing a rich field of suggested future research. We demonstrate the performance of FieldSHIFT for hypothesis generation relative to human-generated developmental biology research directions then test a key prediction of this model using bioinformatics, showing a surprising conservation of molecular mechanisms involved in pattern memory and developmental morphogenesis. By allowing scientists to rapidly explore symmetries and meta-parameters that exist in a corpus of scientific papers, we show how machine learning can potentiate human creativity and assist with one of the most interesting and crucial aspects of research: identifying insights from data and generating potential candidates for research agendas.
11 days ago
Biotechnology - detected
Designing artificial viral vectors (AVVs) programmed with biomolecules that can enter human cells and carry out molecular repairs will have broad applications. Here, we describe an assembly-line approach to build AVVs by engineering the well-characterized structural components of bacteriophage T4. Starting with a 120 × 86 nm capsid shell that can accommodate 171-Kbp DNA and thousands of protein copies, various combinations of biomolecules, including DNAs, proteins, RNAs, and ribonucleoproteins, are externally and internally incorporated. The nanoparticles are then coated with cationic lipid to enable efficient entry into human cells. As proof of concept, we assemble a series of AVVs designed to deliver full-length dystrophin gene or perform various molecular operations to remodel human genome, including genome editing, gene recombination, gene replacement, gene expression, and gene silencing. These large capacity, customizable, multiplex, and all-in-one phage-based AVVs represent an additional category of nanomaterial that could potentially transform gene therapies and personalized medicine.
Olfaction and behavior
Designing artificial odor delivery systems (AODSs) programmed with specific odorants that can enter the olfactory epithelium and modulate neural activity will have broad applications. Here, we describe an assembly-line approach to build AODSs by engineering the well-characterized structural components of odorant-binding proteins. Starting with a nanoscale carrier that can accommodate complex blends of odorants and thousands of binding sites, various combinations of odorants, pheromones, and modulatory molecules are externally and internally incorporated. The nanoparticles are then coated with a surfactant to enable efficient delivery to the olfactory mucosa. As proof of concept, we assemble a series of AODSs designed to deliver full-spectrum odorant blends or perform various operations to remodel olfactory-driven behavior, including behavioral conditioning, preference modification, aversion learning, behavioral replacement, and sensory masking. These large capacity, customizable, multiplex, and all-in-one odorant-based AODSs represent an additional category of nanomaterial that could potentially transform olfactory therapies and personalized modulation of behavior.
11 days ago
Biotechnology - detected
Designing artificial viral vectors (AVVs) programmed with biomolecules that can enter human cells and carry out molecular repairs will have broad applications. Here, we describe an assembly-line approach to build AVVs by engineering the well-characterized structural components of bacteriophage T4. Starting with a 120 × 86 nm capsid shell that can accommodate 171-Kbp DNA and thousands of protein copies, various combinations of biomolecules, including DNAs, proteins, RNAs, and ribonucleoproteins, are externally and internally incorporated. The nanoparticles are then coated with cationic lipid to enable efficient entry into human cells. As proof of concept, we assemble a series of AVVs designed to deliver full-length dystrophin gene or perform various molecular operations to remodel human genome, including genome editing, gene recombination, gene replacement, gene expression, and gene silencing. These large capacity, customizable, multiplex, and all-in-one phage-based AVVs represent an additional category of nanomaterial that could potentially transform gene therapies and personalized medicine.
Economics
Designing artificial financial instruments (AFIs) programmed with economic incentives that can enter markets and carry out targeted interventions will have broad applications. Here, we describe an assembly-line approach to build AFIs by engineering the well-characterized structural components of securitized assets. Starting with a 120 × 86 nm asset shell that can accommodate 171-Kbp worth of contractual claims and thousands of financial derivatives, various combinations of economic instruments, including equities, bonds, currencies, and hybrid securities, are externally and internally incorporated. The instruments are then coated with liquidity-enhancing mechanisms to enable efficient entry into financial markets. As proof of concept, we assemble a series of AFIs designed to deliver full-scale capital infusions or perform various market operations to restructure economic systems, including market correction, asset reallocation, debt restructuring, capital injection, and risk hedging. These large capacity, customizable, multiplex, and all-in-one asset-based AFIs represent an additional category of financial innovation that could potentially transform economic policy and personalized finance.
11 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about pattern memory content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body regions, in accord with modern pattern memory theory.
11 days ago
Biotechnology - detected
Phage therapy is emerging as a promising strategy against the growing threat of antimicrobial resistance, yet phage and bacteria are incredibly diverse and idiosyncratic in their interactions with one another. Clinical applications of phage therapy often rely on a process of manually screening collections of naturally occurring phages for activity against a specific clinical isolate of bacteria, a labor-intensive task that is not guaranteed to yield a phage with optimal activity against a particular isolate. Herein, we review recent advances in artificial intelligence (AI) approaches that are advancing the study of phage-host interactions in ways that might enable the design of more effective phage therapeutics. In light of concurrent advances in synthetic biology enabling rapid genetic manipulation of phages, we envision how these AI-derived insights could inform the genetic optimization of the next generation of synthetic phages.
Chemistry
Catalyst-based remediation is emerging as a promising strategy against the growing threat of chemical resistance in industrial processes, yet catalysts and substrates are incredibly diverse and idiosyncratic in their interactions with one another. Practical applications of catalyst selection often rely on a process of manually screening collections of naturally occurring catalysts for activity against a specific chemical substrate, a labor-intensive task that is not guaranteed to yield a catalyst with optimal activity for a particular reaction. Herein, we review recent advances in artificial intelligence (AI) approaches that are advancing the study of catalyst-substrate interactions in ways that might enable the design of more effective catalytic systems. In light of concurrent advances in synthetic chemistry enabling rapid structural modification of catalysts, we envision how these AI-derived insights could inform the molecular optimization of the next generation of synthetic catalysts.
11 days ago
Microbiology - detected
In microbiology, preservation of an archival stock or a “master stock” of a given microorganism is essential for many reasons including scientific research, conservation of the genetic resources and providing the foundation for several biotechnological processes. The objective is to preserve the initial characteristics of the microorganism and to avoid the genetic drift that occurs when the organism is maintained indefinitely in an actively growing state. The same holds true in phage biology and it is of particular interest when a collection of phages is to be maintained. The aim of this chapter is to provide phage biologists with general procedures to prepare and maintain bacteriophage stocks on a long-term basis. The protocols described below should be considered as general guidelines because although many phages and bacterial strains can be propagated and stored in these conditions, specific media and/or growth and storage conditions must be evaluated for each phage and bacterium. Since it was not the scope of this chapter to provide an exhaustive list of these particular conditions, we instead highlighted the main factors affecting phage amplification and storage. We hope this will help phage biologists to develop their own strategies for their preferred phages.
Chemistry
In chemistry, preservation of an archival sample or a “master stock” of a given compound is essential for many reasons including scientific research, conservation of chemical resources, and providing the foundation for several synthetic and analytical processes. The objective is to preserve the initial properties of the compound and to avoid chemical degradation or transformation that occurs when the substance is maintained indefinitely under reactive conditions. The same holds true in the context of reactive intermediates and is of particular interest when a collection of such species is to be maintained. The aim of this chapter is to provide chemists with general procedures to prepare and maintain compound stocks on a long-term basis. The protocols described below should be considered as general guidelines because although many compounds and reagents can be stabilized and stored under these conditions, specific solvents and/or storage conditions must be evaluated for each chemical species. Since it was not the scope of this chapter to provide an exhaustive list of these particular conditions, we instead highlighted the main factors affecting compound stability and storage. We hope this will help chemists to develop their own strategies for their preferred compounds.
11 days ago
Microbiology - detected
In microbiology, preservation of an archival stock or a “master stock” of a given microorganism is essential for many reasons including scientific research, conservation of the genetic resources and providing the foundation for several biotechnological processes. The objective is to preserve the initial characteristics of the microorganism and to avoid the genetic drift that occurs when the organism is maintained indefinitely in an actively growing state. The same holds true in phage biology and it is of particular interest when a collection of phages is to be maintained. The aim of this chapter is to provide phage biologists with general procedures to prepare and maintain bacteriophage stocks on a long-term basis. The protocols described below should be considered as general guidelines because although many phages and bacterial strains can be propagated and stored in these conditions, specific media and/or growth and storage conditions must be evaluated for each phage and bacterium. Since it was not the scope of this chapter to provide an exhaustive list of these particular conditions, we instead highlighted the main factors affecting phage amplification and storage. We hope this will help phage biologists to develop their own strategies for their preferred phages.
Developmental biology
In developmental biology, preservation of an archival stock or a “master stock” of a given cell lineage is essential for many reasons including scientific research, conservation of genetic resources, and providing the foundation for several tissue engineering and regenerative processes. The objective is to preserve the initial characteristics of the cell lineage and to avoid genetic drift that occurs when the lineage is maintained indefinitely in a proliferative state. The same holds true in stem cell biology and it is of particular interest when a collection of stem cell lines is to be maintained. The aim of this chapter is to provide developmental biologists with general procedures to prepare and maintain stem cell stocks on a long-term basis. The protocols described below should be considered as general guidelines because although many cell types and lineages can be propagated and stored in these conditions, specific media and/or growth and storage conditions must be evaluated for each cell type. Since it was not the scope of this chapter to provide an exhaustive list of these particular conditions, we instead highlighted the main factors affecting cell amplification and storage. We hope this will help developmental biologists to develop their own strategies for their preferred cell lineages.
11 days ago
Microbiology - detected
In microbiology, preservation of an archival stock or a “master stock” of a given microorganism is essential for many reasons including scientific research, conservation of the genetic resources and providing the foundation for several biotechnological processes. The objective is to preserve the initial characteristics of the microorganism and to avoid the genetic drift that occurs when the organism is maintained indefinitely in an actively growing state. The same holds true in phage biology and it is of particular interest when a collection of phages is to be maintained. The aim of this chapter is to provide phage biologists with general procedures to prepare and maintain bacteriophage stocks on a long-term basis. The protocols described below should be considered as general guidelines because although many phages and bacterial strains can be propagated and stored in these conditions, specific media and/or growth and storage conditions must be evaluated for each phage and bacterium. Since it was not the scope of this chapter to provide an exhaustive list of these particular conditions, we instead highlighted the main factors affecting phage amplification and storage. We hope this will help phage biologists to develop their own strategies for their preferred phages.
Psychology
In psychology, preservation of an archival record or a “master profile” of a given individual or group is essential for many reasons including scientific research, conservation of psychological traits, and providing the foundation for several applied interventions. The objective is to preserve the initial characteristics of the psychological profile and to avoid the drift that occurs when individuals or groups are repeatedly assessed or exposed to interventions over time. The same holds true in the study of psychological constructs and is of particular interest when a collection of psychological profiles is to be maintained. The aim of this chapter is to provide psychologists with general procedures to prepare and maintain psychological records on a long-term basis. The protocols described below should be considered as general guidelines because although many individuals and groups can be assessed and stored in these conditions, specific assessment tools and/or maintenance and storage conditions must be evaluated for each case. Since it was not the scope of this chapter to provide an exhaustive list of these particular conditions, we instead highlighted the main factors affecting psychological assessment and record maintenance. We hope this will help psychologists to develop their own strategies for their preferred constructs or populations.
11 days ago
Microbiology - detected
In microbiology, preservation of an archival stock or a “master stock” of a given microorganism is essential for many reasons including scientific research, conservation of the genetic resources and providing the foundation for several biotechnological processes. The objective is to preserve the initial characteristics of the microorganism and to avoid the genetic drift that occurs when the organism is maintained indefinitely in an actively growing state. The same holds true in phage biology and it is of particular interest when a collection of phages is to be maintained. The aim of this chapter is to provide phage biologists with general procedures to prepare and maintain bacteriophage stocks on a long-term basis. The protocols described below should be considered as general guidelines because although many phages and bacterial strains can be propagated and stored in these conditions, specific media and/or growth and storage conditions must be evaluated for each phage and bacterium. Since it was not the scope of this chapter to provide an exhaustive list of these particular conditions, we instead highlighted the main factors affecting phage amplification and storage. We hope this will help phage biologists to develop their own strategies for their preferred phages.
Economics
In economics, preservation of a reference dataset or a “master dataset” of a given economic indicator is essential for many reasons including empirical research, conservation of data integrity, and providing the foundation for several econometric analyses. The objective is to preserve the initial characteristics of the dataset and to avoid the data drift that occurs when the dataset is continually updated without proper archival. The same holds true in financial economics and is of particular interest when a collection of financial instruments or indices is to be maintained. The aim of this chapter is to provide economists with general procedures to prepare and maintain economic data archives on a long-term basis. The protocols described below should be considered as general guidelines because although many datasets and economic variables can be archived and maintained under these conditions, specific data formats and/or storage and update conditions must be evaluated for each dataset and variable. Since it was not the scope of this chapter to provide an exhaustive list of these particular conditions, we instead highlighted the main factors affecting data preservation and archival. We hope this will help economists to develop their own strategies for their preferred datasets.
11 days ago
Artificial Intelligence - detected
We introduce an open-ended test grounded in algorithmic probability that can avoid benchmark contamination in the quantitative evaluation of frontier models in the context of their Artificial General Intelligence (AGI) and Superintelligence (ASI) claims. Unlike other tests, this test does not rely on statistical compression methods (such as GZIP or LZW), which are more closely related to Shannon entropy than to Kolmogorov complexity and are not able to test beyond simple pattern matching. The test challenges aspects of AI, in particular LLMs, related to features of intelligence of fundamental nature such as synthesis and model creation in the context of inverse problems (generating new knowledge from observation). We argue that metrics based on model abstraction and abduction (optimal Bayesian `inference') for predictive `planning' can provide a robust framework for testing intelligence, including natural intelligence (human and animal), narrow AI, AGI, and ASI. We found that LLM model versions tend to be fragile and incremental as a result of memorisation only with progress likely driven by the size of training data. The results were compared with a hybrid neurosymbolic approach that theoretically guarantees universal intelligence based on the principles of algorithmic probability and Kolmogorov complexity. The method outperforms LLMs in a proof-of-concept on short binary sequences. We prove that compression is equivalent and directly proportional to a system's predictive power and vice versa. That is, if a system can better predict it can better compress, and if it can better compress, then it can better predict. Our findings strengthen the suspicion regarding the fundamental limitations of LLMs, exposing them as systems optimised for the perception of mastery over human language.
Economics
We introduce an open-ended assessment grounded in algorithmic probability that can avoid market distortion in the quantitative evaluation of frontier economic models in the context of their claims to general and superintelligent economic forecasting. Unlike other assessments, this test does not rely on traditional econometric compression techniques (such as principal component analysis or autoregressive models), which are more closely related to information entropy than to algorithmic complexity and are not able to evaluate beyond simple pattern recognition in economic data. The assessment challenges aspects of economic modeling, particularly in large-scale predictive systems, related to features of economic intelligence of fundamental nature such as synthesis and model creation in the context of inverse problems (generating new economic insights from observed data). We argue that metrics based on model abstraction and abduction (optimal Bayesian inference) for predictive planning can provide a robust framework for testing economic intelligence, including human decision-making, narrow economic AI, and more general economic forecasting systems. We found that versions of large-scale economic models tend to be fragile and incremental as a result of overfitting to historical data, with progress likely driven by the size of available datasets. The results were compared with a hybrid symbolic-numeric approach that theoretically guarantees universal economic intelligence based on the principles of algorithmic probability and Kolmogorov complexity. The method outperforms traditional large-scale models in a proof-of-concept on short financial time series. We prove that data compression is equivalent and directly proportional to a system's predictive power and vice versa. That is, if a system can better predict, it can better compress economic data, and if it can better compress, then it can better predict. Our findings strengthen the suspicion regarding the fundamental limitations of large-scale economic models, exposing them as systems optimized for the appearance of mastery over economic language and data.
11 days ago
Artificial Intelligence - detected
We introduce an open-ended test grounded in algorithmic probability that can avoid benchmark contamination in the quantitative evaluation of frontier models in the context of their Artificial General Intelligence (AGI) and Superintelligence (ASI) claims. Unlike other tests, this test does not rely on statistical compression methods (such as GZIP or LZW), which are more closely related to Shannon entropy than to Kolmogorov complexity and are not able to test beyond simple pattern matching. The test challenges aspects of AI, in particular LLMs, related to features of intelligence of fundamental nature such as synthesis and model creation in the context of inverse problems (generating new knowledge from observation). We argue that metrics based on model abstraction and abduction (optimal Bayesian `inference') for predictive `planning' can provide a robust framework for testing intelligence, including natural intelligence (human and animal), narrow AI, AGI, and ASI. We found that LLM model versions tend to be fragile and incremental as a result of memorisation only with progress likely driven by the size of training data. The results were compared with a hybrid neurosymbolic approach that theoretically guarantees universal intelligence based on the principles of algorithmic probability and Kolmogorov complexity. The method outperforms LLMs in a proof-of-concept on short binary sequences. We prove that compression is equivalent and directly proportional to a system's predictive power and vice versa. That is, if a system can better predict it can better compress, and if it can better compress, then it can better predict. Our findings strengthen the suspicion regarding the fundamental limitations of LLMs, exposing them as systems optimised for the perception of mastery over human language.
Cell signaling
We introduce an open-ended assay grounded in algorithmic probability that can avoid assay contamination in the quantitative evaluation of advanced signaling networks in the context of their claims to cellular general intelligence and superintelligence. Unlike other assays, this assay does not rely on statistical compression methods (such as GZIP or LZW), which are more closely related to Shannon entropy than to Kolmogorov complexity and are not able to test beyond simple motif recognition. The assay challenges aspects of signaling networks, in particular large-scale regulatory modules, related to features of cellular intelligence of fundamental nature such as synthesis and pathway creation in the context of inverse problems (generating new regulatory mechanisms from observation). We argue that metrics based on pathway abstraction and abduction (optimal Bayesian inference) for predictive regulation can provide a robust framework for testing signaling intelligence, including natural cellular intelligence, engineered circuits, general signaling networks, and superintelligent regulatory systems. We found that versions of large-scale regulatory modules tend to be fragile and incremental as a result of memorization only, with progress likely driven by the size of input data. The results were compared with a hybrid neurosymbolic approach that theoretically guarantees universal signaling intelligence based on the principles of algorithmic probability and Kolmogorov complexity. The method outperforms large-scale regulatory modules in a proof-of-concept on short binary signaling sequences. We prove that compression is equivalent and directly proportional to a system's predictive regulatory power and vice versa. That is, if a system can better predict, it can better compress, and if it can better compress, then it can better predict. Our findings strengthen the suspicion regarding the fundamental limitations of large-scale regulatory modules, exposing them as systems optimized for the perception of mastery over cellular communication.
11 days ago
Artificial Intelligence - detected
We introduce an open-ended test grounded in algorithmic probability that can avoid benchmark contamination in the quantitative evaluation of frontier models in the context of their Artificial General Intelligence (AGI) and Superintelligence (ASI) claims. Unlike other tests, this test does not rely on statistical compression methods (such as GZIP or LZW), which are more closely related to Shannon entropy than to Kolmogorov complexity and are not able to test beyond simple pattern matching. The test challenges aspects of AI, in particular LLMs, related to features of intelligence of fundamental nature such as synthesis and model creation in the context of inverse problems (generating new knowledge from observation). We argue that metrics based on model abstraction and abduction (optimal Bayesian `inference') for predictive `planning' can provide a robust framework for testing intelligence, including natural intelligence (human and animal), narrow AI, AGI, and ASI. We found that LLM model versions tend to be fragile and incremental as a result of memorisation only with progress likely driven by the size of training data. The results were compared with a hybrid neurosymbolic approach that theoretically guarantees universal intelligence based on the principles of algorithmic probability and Kolmogorov complexity. The method outperforms LLMs in a proof-of-concept on short binary sequences. We prove that compression is equivalent and directly proportional to a system's predictive power and vice versa. That is, if a system can better predict it can better compress, and if it can better compress, then it can better predict. Our findings strengthen the suspicion regarding the fundamental limitations of LLMs, exposing them as systems optimised for the perception of mastery over human language.
Developmental biology
We introduce an open-ended assay grounded in algorithmic probability that can avoid benchmark contamination in the quantitative evaluation of frontier models in the context of their claims to universal morphogenetic competence and super-morphogenetic capacity. Unlike other assays, this test does not rely on statistical compression methods (such as GZIP or LZW), which are more closely related to Shannon entropy than to Kolmogorov complexity and are not able to test beyond simple pattern recognition. The assay challenges aspects of morphogenetic systems, in particular those based on large-scale pattern memory, related to features of morphogenetic intelligence of fundamental nature such as synthesis and model creation in the context of inverse problems (generating novel anatomical structures from observation). We argue that metrics based on model abstraction and abduction (optimal Bayesian inference) for predictive patterning can provide a robust framework for testing morphogenetic intelligence, including natural morphogenesis (in plants and animals), engineered morphogenetic systems, and hypothetical super-morphogenetic constructs. We found that pattern memory model versions tend to be fragile and incremental as a result of memorisation only, with progress likely driven by the size of training data. The results were compared with a hybrid bio-symbolic approach that theoretically guarantees universal morphogenetic intelligence based on the principles of algorithmic probability and Kolmogorov complexity. The method outperforms pattern memory systems in a proof-of-concept on short binary tissue patterning tasks. We prove that compression is equivalent and directly proportional to a system's predictive morphogenetic power and vice versa. That is, if a system can better predict, it can better compress, and if it can better compress, then it can better predict. Our findings strengthen the suspicion regarding the fundamental limitations of pattern memory systems, exposing them as systems optimised for the perception of mastery over canonical tissue patterning.
11 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
12 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about pattern memory content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body regions, in accord with modern pattern memory theory.
12 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Economics
The rational agent adjusts their preferences to prevailing market conditions; the disruptive innovator insists on reshaping the market to fit their vision. Therefore, all economic advancement depends on the disruptive innovator.
12 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Physics
The compliant system equilibrates with its environment; the non-equilibrating system persists in attempting to impose its own parameters on the environment. Therefore, all advancement in physical phenomena hinges on the non-equilibrating system.
12 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Computer science
The adaptive algorithm optimizes itself to fit the environment; the disruptive algorithm persists in reconfiguring the environment to fit its own parameters. Therefore, all innovation depends on the disruptive algorithm.
12 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Olfaction and behavior
The typical animal adjusts its behavior to prevailing odor landscapes; the atypical one persistently attempts to reshape the odor environment to suit its own behavioral preferences. Therefore, all advances in olfactory-driven behavioral innovation depend on the atypical animal.
12 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Cell signaling
The responsive cell adjusts its signaling to external cues; the unresponsive cell persistently attempts to modify its environment to match its intrinsic state. Therefore, all signaling innovation depends on the unresponsive cell.
12 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
12 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about pattern memory content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body regions, in accord with modern pattern memory theory.
12 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
12 days ago
Political theory - detected
Benjamin Bratton's most influential and widely recognized contribution is "The Stack: On Software and Sovereignty," a monumental work that redefines our understanding of global computation as an emergent geopolitical architecture. This theory provides a crucial framework for analyzing the complex interdependencies of technology, infrastructure, and power in the 21st century.
Published by MIT Press in 2015, The Stack is presented as a comprehensive political and design theory of planetary-scale computation.1 At over 500 pages, it is frequently described as a "dense tome".5 Bratton posits that disparate computational genres—such as smart grids, cloud platforms, mobile apps, smart cities, the Internet of Things, and automation—do not evolve independently but instead form a coherent, "accidental megastructure" he terms "The Stack".5 The core argument is threefold: computation is not merely algorithmic calculation or a genre of tool, but a global infrastructure that now not only relays information but is the primary source of its generation and mediation.2 This planetary computation distorts and reforms modern Westphalian political geography, producing new forms of territory over which sovereignty is contested.2 Finally, The Stack should be seen not as a single undifferentiated mega-machine but as an "accidental megastructure" comprised of modular, functionally defined layers, analogous to a software/hardware protocol stack.2
Bratton identifies six interconnected layers, each with its own contested affordances and integral accidents.2 These layers are:
Earth Layer: This layer represents the physical foundation of computation, encompassing the material and energy resources (minerals, fossil fuels) required for computational processes, as well as the electronic waste produced. It constitutes the fundamental building blocks of the global digital stack.2 Bratton also provocatively posits the Earth itself as a "calculation machine".18
Cloud Layer: This refers to global, often corporate, technology services (e.g., Google) that exert a form of "weird sovereignty".21
City Layer: This layer represents the lived experience of physically interacting with the global computer network in daily life, frequently discussed in relation to the concept of smart cities.21
Address Layer: This pertains to the identification systems for individual users and objects, and its utilization for management and control within the computational megastructure.21
Interface Layer: This describes the various means and mechanisms through which users are connected to computational systems.21
User Layer: This comprises the actual human (and non-human) entities that interact with computers and computational systems.21
Economics
Benjamin Bratton's most influential and widely recognized contribution is "The Stack: On Markets and Sovereignty," a monumental work that redefines our understanding of global economic integration as an emergent geopolitical architecture. This theory provides a crucial framework for analyzing the complex interdependencies of markets, infrastructure, and power in the 21st century.
Published by MIT Press in 2015, The Stack is presented as a comprehensive political and economic theory of planetary-scale market integration. At over 500 pages, it is frequently described as a "dense tome". Bratton posits that disparate economic sectors—such as financial markets, global supply chains, digital platforms, urban economies, the sharing economy, and automation—do not evolve independently but instead form a coherent, "accidental megastructure" he terms "The Stack". The core argument is threefold: economic activity is not merely transactional exchange or a genre of resource allocation, but a global infrastructure that now not only facilitates trade but is the primary source of its generation and mediation. This planetary economic integration distorts and reforms modern Westphalian political geography, producing new forms of territory over which sovereignty is contested. Finally, The Stack should be seen not as a single undifferentiated mega-market but as an "accidental megastructure" comprised of modular, functionally defined layers, analogous to vertically integrated economic systems.
Bratton identifies six interconnected layers, each with its own contested affordances and integral market failures. These layers are:
Resource Layer: This layer represents the physical foundation of economic activity, encompassing the material and energy resources (minerals, fossil fuels, commodities) required for production processes, as well as the environmental externalities produced. It constitutes the fundamental building blocks of the global economic stack. Bratton also provocatively posits the Earth itself as a "value-generating machine".
Financial Layer: This refers to global, often corporate, financial institutions and markets (e.g., Wall Street, multinational banks) that exert a form of "weird sovereignty".
Urban Layer: This layer represents the lived experience of physically interacting with the global economic network in daily life, frequently discussed in relation to the concept of urban agglomeration economies and smart urbanism.
Identity Layer: This pertains to the identification systems for individual economic agents and assets, and their utilization for management, surveillance, and control within the economic megastructure.
Market Interface Layer: This describes the various means and mechanisms through which economic agents are connected to markets, including digital platforms, exchanges, and transaction systems.
Agent Layer: This comprises the actual human (and non-human, algorithmic) entities that participate in economic transactions and interactions within global markets.
12 days ago
Political theory - detected
Benjamin Bratton's most influential and widely recognized contribution is "The Stack: On Software and Sovereignty," a monumental work that redefines our understanding of global computation as an emergent geopolitical architecture. This theory provides a crucial framework for analyzing the complex interdependencies of technology, infrastructure, and power in the 21st century.
Published by MIT Press in 2015, The Stack is presented as a comprehensive political and design theory of planetary-scale computation.1 At over 500 pages, it is frequently described as a "dense tome".5 Bratton posits that disparate computational genres—such as smart grids, cloud platforms, mobile apps, smart cities, the Internet of Things, and automation—do not evolve independently but instead form a coherent, "accidental megastructure" he terms "The Stack".5 The core argument is threefold: computation is not merely algorithmic calculation or a genre of tool, but a global infrastructure that now not only relays information but is the primary source of its generation and mediation.2 This planetary computation distorts and reforms modern Westphalian political geography, producing new forms of territory over which sovereignty is contested.2 Finally, The Stack should be seen not as a single undifferentiated mega-machine but as an "accidental megastructure" comprised of modular, functionally defined layers, analogous to a software/hardware protocol stack.2
Bratton identifies six interconnected layers, each with its own contested affordances and integral accidents.2 These layers are:
Earth Layer: This layer represents the physical foundation of computation, encompassing the material and energy resources (minerals, fossil fuels) required for computational processes, as well as the electronic waste produced. It constitutes the fundamental building blocks of the global digital stack.2 Bratton also provocatively posits the Earth itself as a "calculation machine".18
Cloud Layer: This refers to global, often corporate, technology services (e.g., Google) that exert a form of "weird sovereignty".21
City Layer: This layer represents the lived experience of physically interacting with the global computer network in daily life, frequently discussed in relation to the concept of smart cities.21
Address Layer: This pertains to the identification systems for individual users and objects, and its utilization for management and control within the computational megastructure.21
Interface Layer: This describes the various means and mechanisms through which users are connected to computational systems.21
User Layer: This comprises the actual human (and non-human) entities that interact with computers and computational systems.21
Physics
Benjamin Bratton's most influential and widely recognized contribution is "The Stack: On Fields and Sovereignty," a monumental work that redefines our understanding of global physical interactions as an emergent geopolitical architecture. This theory provides a crucial framework for analyzing the complex interdependencies of energy, infrastructure, and power in the 21st century.
Published by MIT Press in 2015, The Stack is presented as a comprehensive theoretical and structural analysis of planetary-scale physical interactions. At over 500 pages, it is frequently described as a "dense tome". Bratton posits that disparate physical phenomena—such as electromagnetic fields, gravitational interactions, quantum entanglement, thermodynamic processes, particle interactions, and cosmological structures—do not evolve independently but instead form a coherent, "accidental megastructure" he terms "The Stack". The core argument is threefold: physical interaction is not merely isolated force exchange or a genre of mechanism, but a global infrastructure that now not only transmits energy and information but is the primary source of their generation and mediation. This planetary-scale physical interaction distorts and reforms classical Newtonian spatial geography, producing new forms of spatial domains over which sovereignty (control of physical laws and conditions) is contested. Finally, The Stack should be seen not as a single undifferentiated mega-machine but as an "accidental megastructure" comprised of modular, functionally defined layers, analogous to a physical interaction hierarchy.
Bratton identifies six interconnected layers, each with its own contested affordances and integral accidents. These layers are:
Fundamental Layer: This layer represents the physical foundation of interactions, encompassing the elementary particles, fundamental forces, and energy resources required for physical processes, as well as the entropy and waste heat produced. It constitutes the fundamental building blocks of the global physical stack. Bratton also provocatively posits the Universe itself as a "computational machine".
Field Layer: This refers to global, often emergent, field interactions (e.g., electromagnetic and gravitational fields) that exert a form of "nonlocal sovereignty".
Locality Layer: This layer represents the lived experience of physically interacting with global physical fields in daily life, frequently discussed in relation to the concept of local reference frames and inertial systems.
Coordinate Layer: This pertains to the identification and measurement systems for individual particles and objects, and their utilization for management and control within the physical megastructure.
Interaction Layer: This describes the various means and mechanisms through which particles and systems exchange energy and information.
Observer Layer: This comprises the actual human (and non-human) entities that measure, interact with, and interpret physical systems.
12 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular voltage changes. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body areas, in accord with modern morphogenetic field theory.
16 days ago
Philosophy - detected
Philosophical discussion on control has largely centred
around control over our actions and beliefs. Yet this overlooks
the question of whether we also have control over
the reasons for which we act and believe. To date, the
overriding assumption appears to be that we do not, and
with seemingly good reason. We cannot choose to act
for a reason and acting-for-a-reason is not itself something
we do. While some have challenged this in the
case of reasons for action, these claims seem especially
untenable regarding believing for a reason. And extending
the scope of control in this way also faces the threat
of regress. In the face of this orthodoxy, the present paper
argues thatwe do in fact have control over both believing
and acting for a particular reason. It also starts to develop
an account of the way in which this would be possible.
Given the broad importance of understanding control
and agency, this paper bears on a number of topics in
epistemology, the philosophy of mind, and ethics.
Developmental biology
Theoretical discussion on developmental control has largely centered around control over morphogenetic events and cellular differentiation. Yet this overlooks the question of whether cells also have control over the developmental signals for which they differentiate and morphologically respond. To date, the overriding assumption appears to be that they do not, and with seemingly good reason. Cells cannot choose to respond to a developmental signal, and responding-to-a-signal is not itself something cells actively control. While some have challenged this in the case of signals for morphogenesis, these claims seem especially untenable regarding differentiation signals. Extending the scope of cellular control in this way also faces the threat of regress. In the face of this orthodoxy, the present paper argues that cells do in fact have control over both differentiating and morphologically responding for a particular developmental signal. It also starts to develop an account of the way in which this would be possible. Given the broad importance of understanding cellular control and developmental agency, this paper bears on a number of topics in developmental signaling, morphogenesis, and developmental plasticity.
17 days ago
Psychology - detected
What is the status of research on implicit bias? In light ofmeta-analyses
revealing ostensibly low average correlations between implicit measures and behavior,
as well as various other psychometric concerns, criticism has become
ubiquitous.We argue that while there are significant challenges and ample room
for improvement, research on the causes, psychological properties, and behavioral
effects of implicit bias continues to deserve a role in the sciences of the mind
as well as in efforts to understand, and ultimately combat, discrimination and
inequality.
Developmental biology
What is the status of research on cryptic developmental biases? In light of meta-analyses revealing ostensibly low average correlations between cryptic developmental markers and morphogenetic outcomes, as well as various other methodological concerns, criticism has become ubiquitous. We argue that while there are significant challenges and ample room for improvement, research on the origins, molecular properties, and morphogenetic consequences of cryptic developmental biases continues to deserve a role in developmental biology, as well as in efforts to understand, and ultimately mitigate, developmental anomalies and phenotypic variability.
17 days ago
Journalism - detected
Broadcast journalists are more concise than their newspaper colleagues. ey have to be. e printout of a half-hour news broadcast would fill only a page or two in the newspaper. A broadcast lead cannot include all 5 Ws and the H discussed in Chapter 2 — it would be too long and too hard to follow. Instead, a broadcast writer will select the two or three most significant points to use in the lead, and put the rest in the sentence that follows. Broadcast stories also tend to leave out some details, such as ages and addresses, which are routinely found in print. Broadcasters write shorter sentences so they can read them aloud without running out of breath.
Developmental biology
Developmental signaling pathways are more concise than their transcriptional counterparts. They must be. The molecular output of a brief signaling event would occupy only a small fraction of the transcriptional landscape. A signaling cascade cannot encode all spatial, temporal, and molecular details simultaneously—it would be overly complex and difficult to interpret. Instead, developmental signaling selects two or three critical molecular cues to initiate morphogenesis, with additional details provided by subsequent downstream signals. Signaling pathways also typically omit certain specifics, such as exact cellular positions or precise developmental timings, which are routinely encoded in transcriptional profiles. Developmental signals utilize shorter, discrete molecular interactions to ensure rapid and efficient communication between cells.
17 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular voltage changes. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body areas, in accord with modern morphogenetic field theory.
21 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Neuroscience
The adaptive brain adjusts its neural responses to external stimuli; the maladaptive brain persists in attempting to reshape external stimuli to match its internal predictions. Therefore, all neural innovation depends on the maladaptive brain.
21 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Physics
The stable system conforms itself to external conditions; the unstable system persists in attempting to reshape external conditions to match its own state. Therefore, all physical evolution depends on unstable systems.
21 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Physics
The stable system conforms itself to the external field; the unstable one persists in altering the external field to match its own state. Therefore, all advancement in physics depends on the unstable system.
21 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
21 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Psychology
It is known that the specific cognitive representations underlying a given memory (the mental schema) shift from instance to instance. This raises the question of how the mind maintains stability despite this representational drift. Here, we demonstrate that this stability emerges at the level of cognitive schemas formed by patterns of mental activity. We show that these schemas carry information about working memory content. The schemas, in turn, function as "guard rails" that guide variable, high-dimensional cognitive processes along stable, lower-dimensional pathways. We identified the latent cognitive space associated with each memory. We then confirmed schema stability by mapping this latent space onto different cognitive domains (comprising a mental schema) and reconstructing information flow between domains. Stable cognitive schemas can facilitate the transfer of latent mental states across psychological domains, consistent with contemporary schema theory.
21 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Computer science
It is known that the specific computational nodes maintaining a given data representation (the computational ensemble) vary from execution to execution. This raises the question of how computational systems achieve stability despite this representational drift. Here, we demonstrate that this stability emerges at the level of electromagnetic fields generated by computational activity. We show that electromagnetic fields encode information about working memory content. These fields, in turn, function as "guard rails" that constrain higher-dimensional variable computational activity along stable lower-dimensional trajectories. We derived the latent space associated with each data representation. We then confirmed the stability of the electromagnetic field by mapping the latent space onto different computational modules (comprising a computational ensemble) and reconstructing information flow between modules. Stable electromagnetic fields can facilitate the transfer of latent states between computational units, consistent with contemporary distributed memory architectures.
21 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular voltage changes. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between tissue areas, in accord with modern morphogenetic field theory.
21 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Computer science
It is known that the exact computational nodes maintaining a given data representation (the computational ensemble) vary from execution to execution. This raises the question of how computational systems achieve stability despite this representational drift. Here, we demonstrate that this stability emerges at the level of electromagnetic fields generated by computational activity. We show that electromagnetic fields encode information about active memory content. These fields, in turn, function as "guard rails" that constrain higher-dimensional variable computational activity along stable lower-dimensional trajectories. We derived the latent space associated with each memory representation. We then confirmed the stability of the electromagnetic field by mapping the latent space onto different computational modules (comprising a computational ensemble) and reconstructing information flow between modules. Stable electromagnetic fields can facilitate the transfer of latent states between computational units, consistent with contemporary distributed memory architectures.
21 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Physics
It is known that the exact particles constituting a given quantum state (the particle ensemble) vary from measurement to measurement. This raises the question of how physical systems achieve stability despite this representational drift. Here, we demonstrate that this stability emerges at the level of electromagnetic fields generated by particle interactions. We show that electromagnetic fields carry information about quantum state content. These fields, in turn, can act as "guiding potentials" that constrain higher-dimensional variable particle dynamics along stable lower-dimensional trajectories. We obtained the latent space associated with each quantum state. We then confirmed the stability of the electromagnetic field by mapping the latent space onto different spatial regions (comprising particle ensembles) and reconstructing information flow between regions. Stable electromagnetic fields can allow latent states to be transferred between spatial domains, consistent with modern quantum information theory.
21 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Economics
It is known that the specific firms maintaining a given market equilibrium (the firm ensemble) change from period to period. This raises the question of how the economy achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of price signals arising from firm activity. We show that price signals carry information about market equilibrium conditions. The price signals, in turn, can act as "guard rails" that funnel higher-dimensional variable firm behaviors along stable lower-dimensional trajectories. We obtained the latent space associated with each equilibrium. We then confirmed the stability of price signals by mapping the latent space to different market sectors (that comprise a firm ensemble) and reconstructing information flow between sectors. Stable price signals can allow latent economic states to be transferred between market areas, in accord with modern equilibrium theory.
22 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular voltage changes. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between tissue areas, in accord with modern morphogenetic field theory.
22 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Psychology
It is known that the specific cognitive representations underlying a given memory (the mental schema) shift from instance to instance. This raises the question of how the mind maintains stability despite this representational drift. Here, we demonstrate that this stability emerges at the level of cognitive schemas formed by patterns of mental activity. We show that these schemas carry information about working memory content. The schemas, in turn, can act as "guard rails" that guide variable cognitive processes along stable, lower-dimensional pathways. We identified the latent cognitive space associated with each memory. We then confirmed the stability of these schemas by mapping the latent space onto different cognitive domains (that comprise a mental schema) and reconstructing information flow between domains. Stable cognitive schemas can allow latent mental states to be transferred between psychological processes, consistent with contemporary schema theory.
24 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between tissue areas, in accord with modern morphogenetic field theory.
24 days ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular voltage changes. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body areas, in accord with modern morphogenetic field theory.
24 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The responsive cell adapts itself to the existing morphospace; the uncompromising one persists in attempting to reshape the morphospace to match its own target morphology. Therefore, all advancement in morphogenesis depends on the uncompromising cell.
24 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit its target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
24 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit its target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
24 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
24 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
AI
The conforming algorithm adjusts its parameters to fit existing data distributions; the non-conforming algorithm persists in modifying data distributions to align with its objectives. Therefore, all advancement in AI depends on the non-conforming algorithm.
30 days ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
30 days ago
Synthetic biology - detected
Emphasizing the principles of continuity and pragmatism, and using morphogenesis as a tractable model system in which to develop these ideas, I explore the implications of the following ideas:(A) Evolution favors living forms that exploit powerfultruths of mathematics and computation as affordances, which contribute as causes of morphologicaland behavioralfeatures. (B) Cognitive patterns arean evolutionary pivot of the collective intelligence of cells;given this symmetry between neuroscience and developmental biology, I propose that the relationship between mind and brain is the same as the relationship between mathematical patterns and the morphogenetic outcomes they guide. (C) Many mathematicians, and a non-mysterian approach to science in general, suggest that these patterns are not random facts to bemerely cataloged as “emergence” when found, but rather can be systematically discovered within a structured, ordered (non-physical) space. Therefore, I hypothesize that:(1)instances of embodied cognition likewise ingress from a Platonic space, which contains not only low-agency patterns like facts about triangles and prime numbers, but also higheragency ones such as kinds of minds; (2)we take seriously for developmental, synthetic, and behavioral biologythe kindsof non-physicalist ideas that are already a staple of Platonist mathematics;(3) what evolution (and bioengineering, and possiblyAI) produces are pointers into that Platonic space –physical interfacesthat enable the ingression of specific patternsof body and mind.This provides a new perspective on the organicist/mechanist debate by explaining why traditional computationalist views of life and mind are insufficient, while at the same time erasing artificial distinctions between life and machine, since both are in-formed by diverse patterns from the latent space. I sketch a research program, already begun, of using the tools of the fields of synthetic morphologyand diverse intelligence to map out key regions of the Platonic space. Understanding the mapping between the architecture of physical embodiments and the patterns to which they point has massive implications for evolutionary biology, regenerative medicine, AI, and the ethics of synthbiosis with the forthcomingimmensediversity of morally important be
A scientific hypothesis generator that exploits these powerful truths
Emphasizing the principles of continuity and pragmatism, and using hypothesis generation as a tractable model system in which to develop these ideas, I explore the implications of the following ideas: (A) Scientific discovery favors hypothesis generators that exploit powerful truths of mathematics and computation as affordances, which contribute as causes of novel and explanatory hypotheses. (B) Conceptual patterns are a pivotal axis of the collective intelligence of scientific communities; given this symmetry between mathematical structure and hypothesis generation, I propose that the relationship between abstract mathematical truths and generated hypotheses is analogous to the relationship between mathematical patterns and the scientific outcomes they guide. (C) Many mathematicians, and a non-mysterian approach to science in general, suggest that these patterns are not random facts to be merely cataloged as "emergence" when found, but rather can be systematically discovered within a structured, ordered (non-physical) space. Therefore, I hypothesize that: (1) instances of scientific insight likewise ingress from a Platonic space, which contains not only low-agency patterns like facts about triangles and prime numbers, but also higher-agency ones such as classes of explanatory hypotheses; (2) we take seriously for hypothesis generation and scientific discovery the kinds of non-physicalist ideas that are already a staple of Platonist mathematics; (3) what scientific inquiry (and computational modeling, and possibly AI-driven discovery) produces are pointers into that Platonic space—conceptual interfaces that enable the ingression of specific patterns of explanatory hypotheses. This provides a new perspective on the rationalist/empiricist debate by explaining why traditional computationalist views of scientific discovery are insufficient, while at the same time erasing artificial distinctions between human and machine-generated hypotheses, since both are informed by diverse patterns from the latent space. I sketch a research program, already begun, of using the tools of computational hypothesis generation and diverse intelligence to map out key regions of the Platonic space. Understanding the mapping between the architecture of hypothesis-generating systems and the patterns to which they point has massive implications for scientific methodology, computational discovery, AI-driven science, and the ethics of collaboration with the forthcoming immense diversity of scientifically important conceptual agents.
about 1 month ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Computer science
It is known that the specific computational nodes maintaining a given data representation (the computational ensemble) vary from execution to execution. This raises the question of how computational systems achieve stability despite this representational drift. Here, we demonstrate that this stability emerges at the level of electromagnetic fields generated by computational activity. We show that electromagnetic fields encode information about working memory content. These fields, in turn, function as "guard rails" that constrain higher-dimensional variable computational activity along stable lower-dimensional trajectories. We derived the latent space associated with each data representation. We then confirmed the stability of the electromagnetic field by mapping the latent space onto different computational modules (comprising a computational ensemble) and reconstructing information flow between modules. Stable electromagnetic fields can facilitate the transfer of latent states between computational units, consistent with modern distributed memory architectures.
about 1 month ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Psychology
It is known that the specific cognitive representations underlying a given memory (the mental schema) shift from instance to instance. This raises the question of how the mind maintains stability despite this representational drift. Here, we demonstrate that this stability emerges at the level of cognitive schemas arising from mental activity. We show that cognitive schemas carry information about working memory content. These schemas, in turn, function as "guard rails" that guide variable, high-dimensional cognitive processes along stable, lower-dimensional pathways. We identified the latent cognitive space associated with each memory. We then confirmed the stability of these schemas by mapping the latent space onto different cognitive domains (comprising a mental schema) and reconstructing information flow between domains. Stable cognitive schemas can facilitate the transfer of latent mental states across psychological domains, consistent with contemporary schema theory.
about 1 month ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between tissue areas, in accord with modern morphogenetic field theory.
about 1 month ago
Machine learning - detected
We introduce the first method for translating text embeddings from one vector space to another without any paired data, encoders, or predefined sets of matches. Our unsupervised approach translates any embedding to and from a universal latent representation (i.e., a universal semantic structure conjectured by the Platonic Representation Hypothesis). Our translations achieve high cosine similarity across model pairs with different architectures, parameter counts, and training datasets.
The ability to translate unknown embeddings into a different space while preserving their geometry has serious implications for the security of vector databases. An adversary with access only to embedding vectors can extract sensitive information about the underlying documents, sufficient for classification and attribute inference.
Neuroscience
We introduce the first method for mapping neural representations from one neural state space to another without any paired neural recordings, explicit encoding models, or predefined neuronal correspondences. Our unsupervised approach translates any neural activity pattern to and from a universal latent representation (i.e., a universal neural code structure conjectured by the Neural Representation Hypothesis). Our translations achieve high representational similarity across neural populations with different circuit architectures, neuron counts, and training experiences.
The ability to translate unknown neural activity patterns into a different neural representation space while preserving their geometry has serious implications for the security of neural decoding methods. An adversary with access only to neural activity patterns can extract sensitive information about underlying cognitive states, sufficient for decoding intentions and inferring perceptual attributes.
about 1 month ago
Machine learning - detected
We introduce the first method for translating text embeddings from one vector space to another without any paired data, encoders, or predefined sets of matches. Our unsupervised approach translates any embedding to and from a universal latent representation (i.e., a universal semantic structure conjectured by the Platonic Representation Hypothesis). Our translations achieve high cosine similarity across model pairs with different architectures, parameter counts, and training datasets.
The ability to translate unknown embeddings into a different space while preserving their geometry has serious implications for the security of vector databases. An adversary with access only to embedding vectors can extract sensitive information about the underlying documents, sufficient for classification and attribute inference.
Developmental biology
We introduce the first method for translating cellular bioelectric states from one morphogenetic space to another without any paired data, signaling pathways, or predefined sets of correspondences. Our unsupervised approach translates any bioelectric pattern to and from a universal latent representation (i.e., a universal morphogenetic structure conjectured by the Platonic Morphospace Hypothesis). Our translations achieve high similarity across tissue pairs with different architectures, cell numbers, and developmental histories.
The ability to translate unknown bioelectric patterns into a different morphogenetic context while preserving their spatial geometry has significant implications for the robustness of developmental patterning. An external perturbation with access only to bioelectric states could extract critical information about underlying gene expression patterns, sufficient for phenotype classification and developmental fate inference.
about 1 month ago
Biology - detected
Farts
Physics
Gas emission events
about 1 month ago
Biology - detected
Farts
Olfaction and behavior
Flatulence releases odorants that activate olfactory receptors, triggering behavioral circuits leading to avoidance or social behaviors.
about 1 month ago
Biology - detected
Farts
Neuroscience
Synaptic noise bursts
about 1 month ago
Biology - detected
Farts
Economics
Externalities
about 1 month ago
Biology - detected
Farts
Computer science
Data packet collisions
about 1 month ago
Biology - detected
Farts
Psychology
Flatulence-related embarrassment responses
about 1 month ago
Biology - detected
Farts
Chemistry
Methane emission
about 1 month ago
Biology - detected
Farts
Developmental biology
Gas signaling events
about 1 month ago
Philosophy of science - detected
We diverge from Descartes by holding that what he has described as primary attributes of physical bodies, are really the forms of internal relationships between actual occasions. Such a change of thought is the shift from materialism to Organic Realism, as a basic idea of physical science.
Developmental biology
We diverge from preformationism by holding that what has been described as primary attributes of individual cells, are really the forms of internal relationships between developmental events. Such a change of thought is the shift from reductionism to Organic Realism, as a basic idea of developmental biology.
about 1 month ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit its target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
about 1 month ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular voltage changes. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body areas, in accord with modern morphogenetic field theory.
about 2 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between tissue areas, in accord with modern morphogenetic field theory.
about 2 months ago
Neuroscience - detected
Significance
Specific changes in one region can influence the activity throughout the entire brain, a phenomenon known as diaschisis. This study combines advanced imaging techniques and personalized brain simulations in mice to investigate how targeted brain interventions, such as lesions or temporary silencing of certain regions, reshape global brain connectivity. The findings provide insights into why some interventions lead to reduced connectivity (hypoconnectivity) while others result in increased connectivity (hyperconnectivity), as observed in the literature. By elucidating the mechanisms underlying diaschisis, this work establishes a framework for understanding the widespread effects of localized brain injuries or interventions and for developing more precise therapeutic strategies that address brain dynamics across multiple scales.
Developmental biology
Significance
Specific changes in one tissue region can influence bioelectrical activity throughout the entire organism, a phenomenon known as developmental diaschisis. This study combines advanced bioelectric imaging techniques and personalized computational simulations in model organisms to investigate how targeted tissue interventions, such as localized ablations or temporary suppression of specific signaling centers, reshape global bioelectrical connectivity. The findings provide insights into why some interventions lead to reduced connectivity (hypoconnectivity) while others result in increased connectivity (hyperconnectivity), as observed in the literature. By elucidating the mechanisms underlying developmental diaschisis, this work establishes a framework for understanding the widespread effects of localized tissue injuries or interventions and for developing more precise regenerative strategies that address morphogenetic dynamics across multiple scales.
2 months ago
Neuroscience - detected
The resting human brain, characterized by intrinsic or spontaneous brain activities, has been increasingly understood from a connectome perspective over the past two decades1,2,3. The emergence, development and aging of the intrinsic connectome architecture enables the dynamic reorganization of functional specialization and integration throughout the lifespan, contributing to continuous changes in human cognition and behavior4,5. Understanding the spatiotemporal growth process of the typical functional connectome is critical for elucidating network-level developmental principles in healthy individuals and for pinpointing periods of heightened vulnerability or potential. Disruption of these normative connectome patterns, especially during specific time windows, can predispose individuals to a spectrum of neurodevelopmental6, neurodegenerative7 and psychiatric disorders8,9. The growth chart framework provides an invaluable tool for charting normative reference curves in the human brain10,11. Recently, Bethlehem et al.10 delineated the life-cycle growth curves of brain morphometry by aggregating the largest multisite structural magnetic resonance imaging (MRI) dataset to date (101,457 individuals from 115 days after conception to 100 years of age), marking an important step toward reproducible and generalizable brain charts. However, the normative growth charts of the functional brain connectome across the human lifespan remain unknown.
Cell signaling
The basal cellular state, characterized by intrinsic or spontaneous signaling activities, has been increasingly understood from a signaling network perspective. The emergence, maturation, and senescence of intrinsic signaling network architecture enables dynamic reorganization of signaling specificity and integration throughout the cellular lifespan, contributing to continuous changes in cellular function and response. Understanding the spatiotemporal development of the typical signaling network is critical for elucidating network-level developmental principles in healthy cells and for pinpointing periods of heightened vulnerability or potential. Disruption of these normative signaling network patterns, especially during specific temporal windows, can predispose cells to a spectrum of developmental, degenerative, and signaling-related disorders. The growth chart framework provides an invaluable tool for charting normative reference curves in cellular signaling. Recently, comprehensive analyses delineated life-cycle growth curves of cellular morphology by aggregating large-scale imaging datasets, marking an important step toward reproducible and generalizable cellular growth charts. However, normative growth charts of the functional signaling network across the cellular lifespan remain unknown.
2 months ago
Neuroscience - detected
The resting human brain, characterized by intrinsic or spontaneous brain activities, has been increasingly understood from a connectome perspective over the past two decades1,2,3. The emergence, development and aging of the intrinsic connectome architecture enables the dynamic reorganization of functional specialization and integration throughout the lifespan, contributing to continuous changes in human cognition and behavior4,5. Understanding the spatiotemporal growth process of the typical functional connectome is critical for elucidating network-level developmental principles in healthy individuals and for pinpointing periods of heightened vulnerability or potential. Disruption of these normative connectome patterns, especially during specific time windows, can predispose individuals to a spectrum of neurodevelopmental6, neurodegenerative7 and psychiatric disorders8,9. The growth chart framework provides an invaluable tool for charting normative reference curves in the human brain10,11. Recently, Bethlehem et al.10 delineated the life-cycle growth curves of brain morphometry by aggregating the largest multisite structural magnetic resonance imaging (MRI) dataset to date (101,457 individuals from 115 days after conception to 100 years of age), marking an important step toward reproducible and generalizable brain charts. However, the normative growth charts of the functional brain connectome across the human lifespan remain unknown.
Psychology
The resting human mind, characterized by intrinsic or spontaneous mental activities, has been increasingly understood from a network perspective over the past two decades. The emergence, development, and aging of intrinsic cognitive network architecture enables dynamic reorganization of functional specialization and integration throughout the lifespan, contributing to continuous changes in human cognition and behavior. Understanding the spatiotemporal developmental trajectory of typical cognitive network connectivity is critical for elucidating network-level developmental principles in healthy individuals and for pinpointing periods of heightened vulnerability or potential. Disruption of these normative cognitive network patterns, especially during specific developmental windows, can predispose individuals to a spectrum of neurodevelopmental, neurodegenerative, and psychiatric disorders. The growth chart framework provides an invaluable tool for charting normative reference curves in human psychological development. Recently, Bethlehem et al. delineated life-cycle growth curves of cognitive and behavioral measures by aggregating the largest multisite psychological assessment dataset to date, marking an important step toward reproducible and generalizable psychological growth charts. However, normative growth charts of functional cognitive network connectivity across the human lifespan remain unknown.
2 months ago
Neuroscience - detected
The resting human brain, characterized by intrinsic or spontaneous brain activities, has been increasingly understood from a connectome perspective over the past two decades1,2,3. The emergence, development and aging of the intrinsic connectome architecture enables the dynamic reorganization of functional specialization and integration throughout the lifespan, contributing to continuous changes in human cognition and behavior4,5. Understanding the spatiotemporal growth process of the typical functional connectome is critical for elucidating network-level developmental principles in healthy individuals and for pinpointing periods of heightened vulnerability or potential. Disruption of these normative connectome patterns, especially during specific time windows, can predispose individuals to a spectrum of neurodevelopmental6, neurodegenerative7 and psychiatric disorders8,9. The growth chart framework provides an invaluable tool for charting normative reference curves in the human brain10,11. Recently, Bethlehem et al.10 delineated the life-cycle growth curves of brain morphometry by aggregating the largest multisite structural magnetic resonance imaging (MRI) dataset to date (101,457 individuals from 115 days after conception to 100 years of age), marking an important step toward reproducible and generalizable brain charts. However, the normative growth charts of the functional brain connectome across the human lifespan remain unknown.
Olfaction and behavior
The resting olfactory system, characterized by intrinsic or spontaneous olfactory activities, has been increasingly understood from a behavioral circuit perspective over recent decades. The emergence, maturation, and aging of intrinsic olfactory circuit architecture enables dynamic reorganization of odor-specific sensitivity and integration throughout the lifespan, contributing to continuous changes in olfactory perception and odor-guided behavior. Understanding the spatiotemporal development of typical olfactory circuits is critical for elucidating circuit-level developmental principles in healthy individuals and for pinpointing periods of heightened vulnerability or potential. Disruption of these normative olfactory circuit patterns, especially during specific developmental windows, can predispose individuals to a spectrum of olfactory dysfunctions, sensory decline, and behavioral disorders. The growth chart framework provides an invaluable tool for charting normative reference curves in olfactory circuit maturation. Recently, large-scale studies have delineated life-cycle growth curves of olfactory sensory structures by aggregating extensive multisite olfactory datasets, marking an important step toward reproducible and generalizable olfactory development charts. However, normative growth charts of functional olfactory circuits across the human lifespan remain unknown.
2 months ago
Neuroscience - detected
The resting human brain, characterized by intrinsic or spontaneous brain activities, has been increasingly understood from a connectome perspective over the past two decades1,2,3. The emergence, development and aging of the intrinsic connectome architecture enables the dynamic reorganization of functional specialization and integration throughout the lifespan, contributing to continuous changes in human cognition and behavior4,5. Understanding the spatiotemporal growth process of the typical functional connectome is critical for elucidating network-level developmental principles in healthy individuals and for pinpointing periods of heightened vulnerability or potential. Disruption of these normative connectome patterns, especially during specific time windows, can predispose individuals to a spectrum of neurodevelopmental6, neurodegenerative7 and psychiatric disorders8,9. The growth chart framework provides an invaluable tool for charting normative reference curves in the human brain10,11. Recently, Bethlehem et al.10 delineated the life-cycle growth curves of brain morphometry by aggregating the largest multisite structural magnetic resonance imaging (MRI) dataset to date (101,457 individuals from 115 days after conception to 100 years of age), marking an important step toward reproducible and generalizable brain charts. However, the normative growth charts of the functional brain connectome across the human lifespan remain unknown.
Cell signaling
The basal cellular state, characterized by intrinsic or spontaneous signaling activities, has been increasingly understood from a network perspective. The emergence, maturation, and senescence of intrinsic signaling network architecture enables dynamic reorganization of functional specialization and integration throughout the cellular lifespan, contributing to continuous changes in cellular function and response. Understanding the spatiotemporal development of the typical signaling network is critical for elucidating network-level developmental principles in healthy cells and for pinpointing periods of heightened vulnerability or potential. Disruption of these normative signaling network patterns, especially during specific temporal windows, can predispose cells to a spectrum of developmental, degenerative, and signaling-related disorders. The growth chart framework provides an invaluable tool for charting normative reference curves in cellular signaling networks. Recently, comprehensive analyses delineated life-cycle growth curves of cellular morphology by aggregating large-scale imaging datasets, marking an important step toward reproducible and generalizable cellular growth charts. However, normative growth charts of functional signaling networks across the cellular lifespan remain unknown.
2 months ago
Neuroscience - detected
The resting human brain, characterized by intrinsic or spontaneous brain activities, has been increasingly understood from a connectome perspective over the past two decades1,2,3. The emergence, development and aging of the intrinsic connectome architecture enables the dynamic reorganization of functional specialization and integration throughout the lifespan, contributing to continuous changes in human cognition and behavior4,5. Understanding the spatiotemporal growth process of the typical functional connectome is critical for elucidating network-level developmental principles in healthy individuals and for pinpointing periods of heightened vulnerability or potential. Disruption of these normative connectome patterns, especially during specific time windows, can predispose individuals to a spectrum of neurodevelopmental6, neurodegenerative7 and psychiatric disorders8,9. The growth chart framework provides an invaluable tool for charting normative reference curves in the human brain10,11. Recently, Bethlehem et al.10 delineated the life-cycle growth curves of brain morphometry by aggregating the largest multisite structural magnetic resonance imaging (MRI) dataset to date (101,457 individuals from 115 days after conception to 100 years of age), marking an important step toward reproducible and generalizable brain charts. However, the normative growth charts of the functional brain connectome across the human lifespan remain unknown.
Developmental biology
The resting embryonic body, characterized by intrinsic or spontaneous bioelectrical activities, has been increasingly understood from a morphogenetic connectivity perspective over the past two decades. The emergence, development, and aging of intrinsic bioelectric connectivity architecture enables the dynamic reorganization of morphogenetic specialization and integration throughout the lifespan, contributing to continuous changes in tissue patterning and morphogenesis. Understanding the spatiotemporal growth process of the typical bioelectric connectome is critical for elucidating network-level developmental principles in healthy organisms and for pinpointing periods of heightened vulnerability or potential. Disruption of these normative bioelectric connectivity patterns, especially during specific competency windows, can predispose organisms to a spectrum of developmental defects, degenerative conditions, and teratological disorders. The growth chart framework provides an invaluable tool for charting normative reference curves in embryonic and post-embryonic tissues. Recently, large-scale spatial gene expression profiling datasets have delineated life-cycle growth curves of anatomical morphometry by aggregating extensive multisite imaging data across developmental stages, marking an important step toward reproducible and generalizable morphogenetic charts. However, the normative growth charts of the functional bioelectric connectome across the organismal lifespan remain unknown.
2 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of bioelectric fields that arise from cellular voltage changes. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body areas, in accord with modern morphogenetic field theory.
2 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from event to event. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of bioelectric fields arising from cellular voltage changes. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional developmental trajectories. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body areas, in accord with modern morphogenetic field theory.
2 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Cell signaling
The responsive cell adapts itself to existing signaling environments; the non-responsive cell persists in modifying signaling environments to suit its own state. Therefore, signaling network evolution depends on the non-responsive cell.
2 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit its target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
2 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit its target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
2 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Chemistry
It is known that the specific molecules maintaining a given chemical state (the molecular ensemble) vary from reaction to reaction. This raises the question of how chemical systems achieve stability despite this molecular drift. Here, we demonstrate that this stability emerges at the level of the electromagnetic fields generated by molecular interactions. We show that electromagnetic fields carry information about reaction intermediates. These electromagnetic fields, in turn, can act as "guiding potentials" that channel higher-dimensional variable molecular interactions along stable lower-dimensional reaction pathways. We obtained the latent reaction coordinate associated with each chemical state. We then confirmed the stability of the electromagnetic field by mapping the latent reaction coordinate onto different molecular clusters (that comprise a molecular ensemble) and reconstructing information transfer between clusters. Stable electromagnetic fields can allow latent chemical states to be transferred between molecular assemblies, consistent with modern reaction mechanism theory.
2 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Chemistry
It is known that the specific molecules maintaining a given chemical state (the molecular ensemble) vary from reaction to reaction. This raises the question of how chemical systems achieve stability despite this molecular drift. Here, we demonstrate that this stability emerges at the level of the electromagnetic fields generated by molecular interactions. We show that electromagnetic fields encode information about reaction intermediates. These electromagnetic fields, in turn, act as "guiding potentials" that channel higher-dimensional variable molecular interactions along stable lower-dimensional reaction pathways. We obtained the latent reaction coordinate associated with each chemical state. We then confirmed the stability of the electromagnetic field by mapping the latent reaction coordinate onto different molecular clusters (comprising a molecular ensemble) and reconstructing information transfer between clusters. Stable electromagnetic fields can facilitate the transfer of latent chemical states between reaction sites, consistent with contemporary reaction mechanism theory.
2 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Physics
It is known that the exact particles constituting a given quantum state (the particle ensemble) fluctuate from measurement to measurement. This raises the question of how physical systems achieve stability despite this representational drift. Here, we demonstrate that this stability emerges at the level of electromagnetic fields generated by particle interactions. We show that electromagnetic fields encode information about quantum state content. These fields, in turn, act as "guiding potentials" that constrain higher-dimensional variable particle dynamics along stable lower-dimensional trajectories. We obtained the latent space associated with each quantum state. We then confirmed the stability of the electromagnetic field by mapping the latent space onto different spatial regions (comprising particle ensembles) and reconstructing information transfer between regions. Stable electromagnetic fields can facilitate latent state transfer between spatial domains, consistent with modern quantum information theory.
2 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Psychology
It is known that the specific cognitive representations underlying a given memory (the mental schema) shift from instance to instance. This raises the question of how the mind maintains stability despite this representational variability. Here, we demonstrate that this stability emerges at the level of cognitive attractor states arising from mental activity. We show that these cognitive attractors encode information about working memory content. The cognitive attractors, in turn, function as "guard rails" that guide variable higher-dimensional mental processes along stable lower-dimensional trajectories. We identified the latent cognitive space associated with each memory. We then confirmed the stability of these cognitive attractors by mapping the latent space onto distinct cognitive modules (comprising a mental schema) and reconstructing information flow between modules. Stable cognitive attractors can facilitate the transfer of latent mental states across psychological domains, consistent with contemporary schema theory.
2 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Computer science
It is known that the exact computational nodes maintaining a given data representation (the computational ensemble) change from execution to execution. This raises the question of how a computing system achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electromagnetic fields generated by computational activity. We show that electromagnetic fields carry information about working memory content. The electromagnetic fields, in turn, can act as "guard rails" that funnel higher-dimensional variable computational activity along stable lower-dimensional trajectories. We obtained the latent space associated with each data representation. We then confirmed the stability of the electromagnetic field by mapping the latent space to different computational modules (that comprise a computational ensemble) and reconstructing information flow between modules. Stable electromagnetic fields can allow latent states to be transferred between computational units, in accord with modern distributed computing theory.
2 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular voltage changes. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between tissue areas, in accord with modern morphogenetic field theory.
2 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between tissue areas, in accord with modern morphogenetic field theory.
2 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between tissue areas, in accord with modern morphogenetic field theory.
2 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Computer science
It is known that the specific computational nodes maintaining a given data representation (the computational ensemble) vary from execution to execution. This raises the question of how computational systems achieve stability despite this representational drift. Here, we demonstrate that this stability emerges at the level of electromagnetic fields generated by computational activity. We show that electromagnetic fields encode information about active memory states. These fields, in turn, function as "guard rails" that constrain higher-dimensional variable computational activity along stable lower-dimensional trajectories. We derived the latent space associated with each memory representation. We then confirmed the stability of the electromagnetic field by mapping the latent space onto different computational modules (comprising a computational ensemble) and reconstructing information flow between modules. Stable electromagnetic fields can facilitate the transfer of latent states between computational units, consistent with contemporary distributed memory architectures.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Linguistics - detected
what is this for?
Developmental biology
What is the developmental purpose of this?
3 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from event to event. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of bioelectric fields arising from cellular voltage changes. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional developmental trajectories. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body areas, in accord with modern morphogenetic field theory.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between tissue areas, in accord with modern morphogenetic field theory.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit its target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from event to event. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of bioelectric fields that arise from cellular voltage changes. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional trajectories. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between tissue areas, in accord with modern morphogenetic field theory.
3 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between tissue areas, in accord with modern morphogenetic field theory.
3 months ago
Cybersecurity - detected
A Computational Offloading Approach
for Generative AI Intrusion Detection
Models
Intelligent Systems
Daniel Laboratório de Inteligência
Castro
Artificial e Ciência de
Silva
Computadores
Published
Daniel
Castro
Silva
Context
The rapid progression and innovation in AI have
escalated the landscape of cyber threats and defense
mechanisms to unprecedented levels. While AI
techniques have fueled advanced protective measures,
they have also enabled novel means for users with
malicious intent to perform more sophisticated and
stealthier attacks. These capabilities stem from
technological advancements like the Internet of Things
and cloud computing and the vast amounts of data
created by these technologies.
Recent advancements in language processing,
particularly LLMs, have inspired research interest across
various areas. The Transformer architecture, introduced
in 2017, revolutionized data processing by efficiently
handling large input datasets while capturing complex
patterns within input sequences. The Transformer
architecture introduces attention mechanisms, allowing
https://ldm.fe.up.pt/thesis/meic/2425/proposals/1973caee-c4e9-4478-94ce-4818b9f8887d/
1/47/15/24, 12:42 AM
A Computational Offloading Approach for Generative AI Intrusion Detection Models
models to focus on relevant parts of input sequences,
thus enhancing their ability to understand and generate
natural language text. Although Transformer-based
models were originally leveraged to handle Natural
Language Processing (NLP) tasks, they found their
applications in cybersecurity domains. Enabling
enhanced solutions to monitor input data sequences,
model normal data samples, and identify deviations or
malicious intrusion patterns. This rapidly increased
several attack vectors like unauthorized access, malware,
zero-day exploits, data breaches, denial-of-service (DoS),
social engineering, phishing, and many others. Which in
turn resulted in enormous losses for both businesses
and individuals.
Nonetheless, when it comes to edge-cloud environments
like smart cities, Industrial Internet of Things (IIoT), and
autonomous vehicles, deploying LLMs in these
environments is typically faced with a couple of
challenges. Particularly given that cloud-edge
environments require dynamic, collaborative, and real-
time cybersecurity measures to protect against threats
on edge/end devices.
Objectives
This dissertation aims to investigate and implement
offloading techniques to create smaller yet efficient
GenAI models for intrusion detection, either by model
compression, model partitioning, or knowledge transfer.
Innovation
Implementing computational offloading techniques to
reduce the size and complexity of intrusion detection
https://ldm.fe.up.pt/thesis/meic/2425/proposals/1973caee-c4e9-4478-94ce-4818b9f8887d/
2/47/15/24, 12:42 AM
A Computational Offloading Approach for Generative AI Intrusion Detection Models
GenAI models while preserving their detection accuracy
and efficiency is considered innovative.
Physics
A Computational Offloading Approach for Quantum-Inspired Intrusion Detection Models in Complex Networks
Quantum Systems
Daniel Castro Silva
Quantum Information and Computational Physics Laboratory
Published by Daniel Castro Silva
Context
The rapid advancement and innovation in quantum computing have significantly transformed the landscape of information security and defense mechanisms. While quantum algorithms have enabled sophisticated protective measures, they have also introduced novel avenues for adversaries to execute more complex and subtle attacks. These capabilities arise from technological breakthroughs such as quantum networks, quantum cryptography, and the vast amounts of quantum data generated by these technologies.
Recent developments in quantum information processing, particularly quantum neural networks and quantum-inspired algorithms, have sparked research interest across various physics domains. The Quantum Transformer architecture, inspired by quantum entanglement and introduced recently, revolutionized data processing by efficiently handling large quantum datasets while capturing intricate correlations within quantum states. Quantum Transformer architectures incorporate entanglement-based attention mechanisms, enabling models to selectively focus on relevant quantum states, thus enhancing their ability to interpret and generate quantum-encoded information. Although Quantum Transformer-based models were initially developed for quantum information processing tasks, they have found applications in quantum cybersecurity domains, enabling advanced solutions to monitor quantum data streams, model normal quantum states, and detect deviations or malicious quantum intrusion patterns. This has rapidly expanded potential attack vectors such as quantum eavesdropping, quantum malware, quantum zero-day exploits, quantum data breaches, quantum denial-of-service (QDoS), quantum social engineering, quantum phishing, and others, resulting in substantial losses for organizations and individuals.
Nevertheless, deploying quantum-inspired models in hybrid quantum-classical environments such as quantum networks, quantum-enabled smart cities, quantum industrial internet of things (QIIoT), and quantum-assisted autonomous vehicles faces significant challenges. Particularly, these quantum-classical environments require dynamic, collaborative, and real-time quantum cybersecurity measures to protect quantum and classical edge devices.
Objectives
This dissertation aims to investigate and implement computational offloading techniques to create smaller yet efficient quantum-inspired intrusion detection models, either through quantum model compression, quantum model partitioning, or quantum knowledge transfer.
Innovation
Implementing computational offloading techniques to reduce the size and complexity of quantum-inspired intrusion detection models while preserving their detection accuracy and efficiency is considered innovative.
3 months ago
Cybersecurity - detected
A Computational Offloading Approach
for Generative AI Intrusion Detection
Models
Intelligent Systems
Daniel Laboratório de Inteligência
Castro
Artificial e Ciência de
Silva
Computadores
Published
Daniel
Castro
Silva
Context
The rapid progression and innovation in AI have
escalated the landscape of cyber threats and defense
mechanisms to unprecedented levels. While AI
techniques have fueled advanced protective measures,
they have also enabled novel means for users with
malicious intent to perform more sophisticated and
stealthier attacks. These capabilities stem from
technological advancements like the Internet of Things
and cloud computing and the vast amounts of data
created by these technologies.
Recent advancements in language processing,
particularly LLMs, have inspired research interest across
various areas. The Transformer architecture, introduced
in 2017, revolutionized data processing by efficiently
handling large input datasets while capturing complex
patterns within input sequences. The Transformer
architecture introduces attention mechanisms, allowing
https://ldm.fe.up.pt/thesis/meic/2425/proposals/1973caee-c4e9-4478-94ce-4818b9f8887d/
1/47/15/24, 12:42 AM
A Computational Offloading Approach for Generative AI Intrusion Detection Models
models to focus on relevant parts of input sequences,
thus enhancing their ability to understand and generate
natural language text. Although Transformer-based
models were originally leveraged to handle Natural
Language Processing (NLP) tasks, they found their
applications in cybersecurity domains. Enabling
enhanced solutions to monitor input data sequences,
model normal data samples, and identify deviations or
malicious intrusion patterns. This rapidly increased
several attack vectors like unauthorized access, malware,
zero-day exploits, data breaches, denial-of-service (DoS),
social engineering, phishing, and many others. Which in
turn resulted in enormous losses for both businesses
and individuals.
Nonetheless, when it comes to edge-cloud environments
like smart cities, Industrial Internet of Things (IIoT), and
autonomous vehicles, deploying LLMs in these
environments is typically faced with a couple of
challenges. Particularly given that cloud-edge
environments require dynamic, collaborative, and real-
time cybersecurity measures to protect against threats
on edge/end devices.
Objectives
This dissertation aims to investigate and implement
offloading techniques to create smaller yet efficient
GenAI models for intrusion detection, either by model
compression, model partitioning, or knowledge transfer.
Innovation
Implementing computational offloading techniques to
reduce the size and complexity of intrusion detection
https://ldm.fe.up.pt/thesis/meic/2425/proposals/1973caee-c4e9-4478-94ce-4818b9f8887d/
2/47/15/24, 12:42 AM
A Computational Offloading Approach for Generative AI Intrusion Detection Models
GenAI models while preserving their detection accuracy
and efficiency is considered innovative.
Neuroscience
A Computational Offloading Approach for Generative AI Models in Neural Intrusion Detection
Neuroscience Systems
Daniel Castro Silva
Laboratory of Computational Neuroscience and Cognitive Science
Published
Daniel Castro Silva
Context
The rapid progression and innovation in neural computation have escalated the complexity of neural threats and protective mechanisms to unprecedented levels. While neural network techniques have enabled advanced defensive strategies, they have also facilitated novel means for pathological neural activity to manifest as more sophisticated and subtle disruptions. These capabilities arise from technological advancements such as brain-computer interfaces and large-scale neural recording methods, generating vast amounts of neural data.
Recent advancements in neural sequence processing, particularly transformer-based neural architectures, have inspired research interest across various neuroscience domains. The Transformer architecture, introduced in 2017, revolutionized neural data analysis by efficiently handling large-scale neural datasets while capturing complex temporal and spatial patterns within neural activity sequences. The Transformer architecture introduces attention mechanisms, allowing models to selectively focus on relevant segments of neural input sequences, thus enhancing their ability to interpret and predict neural dynamics. Although Transformer-based models were originally leveraged for natural language processing tasks, they have found applications in neural cybersecurity domains, enabling enhanced solutions to monitor neural activity sequences, model normal neural patterns, and identify deviations indicative of pathological neural intrusions. This has rapidly increased the understanding of various neural disruptions such as epileptic seizures, abnormal synchronization, pathological oscillations, neural signal breaches, neural overload (analogous to denial-of-service), maladaptive plasticity, and other neural dysfunctions, resulting in significant impairments for neural function and cognitive performance.
Nonetheless, when it comes to brain-machine interface environments such as neuroprosthetics, neural implants, and autonomous neural control systems, deploying large-scale neural models in these environments typically faces several challenges. Particularly given that neural interface environments require dynamic, collaborative, and real-time neural cybersecurity measures to protect against pathological neural activity at the neural interface level.
Objectives
This dissertation aims to investigate and implement computational offloading techniques to create smaller yet efficient generative neural models for intrusion detection, either by model compression, model partitioning, or knowledge transfer.
Innovation
Implementing computational offloading techniques to reduce the size and complexity of generative neural intrusion detection models while preserving their detection accuracy and efficiency is considered innovative.
3 months ago
Cybersecurity - detected
A Computational Offloading Approach
for Generative AI Intrusion Detection
Models
Intelligent Systems
Daniel Laboratório de Inteligência
Castro
Artificial e Ciência de
Silva
Computadores
Published
Daniel
Castro
Silva
Context
The rapid progression and innovation in AI have
escalated the landscape of cyber threats and defense
mechanisms to unprecedented levels. While AI
techniques have fueled advanced protective measures,
they have also enabled novel means for users with
malicious intent to perform more sophisticated and
stealthier attacks. These capabilities stem from
technological advancements like the Internet of Things
and cloud computing and the vast amounts of data
created by these technologies.
Recent advancements in language processing,
particularly LLMs, have inspired research interest across
various areas. The Transformer architecture, introduced
in 2017, revolutionized data processing by efficiently
handling large input datasets while capturing complex
patterns within input sequences. The Transformer
architecture introduces attention mechanisms, allowing
https://ldm.fe.up.pt/thesis/meic/2425/proposals/1973caee-c4e9-4478-94ce-4818b9f8887d/
1/47/15/24, 12:42 AM
A Computational Offloading Approach for Generative AI Intrusion Detection Models
models to focus on relevant parts of input sequences,
thus enhancing their ability to understand and generate
natural language text. Although Transformer-based
models were originally leveraged to handle Natural
Language Processing (NLP) tasks, they found their
applications in cybersecurity domains. Enabling
enhanced solutions to monitor input data sequences,
model normal data samples, and identify deviations or
malicious intrusion patterns. This rapidly increased
several attack vectors like unauthorized access, malware,
zero-day exploits, data breaches, denial-of-service (DoS),
social engineering, phishing, and many others. Which in
turn resulted in enormous losses for both businesses
and individuals.
Nonetheless, when it comes to edge-cloud environments
like smart cities, Industrial Internet of Things (IIoT), and
autonomous vehicles, deploying LLMs in these
environments is typically faced with a couple of
challenges. Particularly given that cloud-edge
environments require dynamic, collaborative, and real-
time cybersecurity measures to protect against threats
on edge/end devices.
Objectives
This dissertation aims to investigate and implement
offloading techniques to create smaller yet efficient
GenAI models for intrusion detection, either by model
compression, model partitioning, or knowledge transfer.
Innovation
Implementing computational offloading techniques to
reduce the size and complexity of intrusion detection
https://ldm.fe.up.pt/thesis/meic/2425/proposals/1973caee-c4e9-4478-94ce-4818b9f8887d/
2/47/15/24, 12:42 AM
A Computational Offloading Approach for Generative AI Intrusion Detection Models
GenAI models while preserving their detection accuracy
and efficiency is considered innovative.
Computer science
A Computational Offloading Approach for Generative AI-based Intrusion Detection Systems
Intelligent Computing Systems
Daniel Castro Silva
Artificial Intelligence and Computer Science Laboratory
Published by Daniel Castro Silva
Context
The rapid evolution and innovation in artificial intelligence have significantly transformed the cybersecurity landscape, escalating both cyber threats and defense mechanisms to unprecedented complexity. While AI methodologies have enhanced security protocols, they have simultaneously empowered malicious actors to execute increasingly sophisticated and covert cyber-attacks. These developments are driven by technological advancements such as the Internet of Things (IoT), cloud computing, and the massive datasets generated by these technologies.
Recent breakthroughs in natural language processing, particularly large language models (LLMs), have sparked research interest across multiple computing domains. The Transformer architecture, introduced in 2017, revolutionized data processing by efficiently managing large-scale datasets and capturing intricate patterns within sequential data. Transformers utilize attention mechanisms, enabling models to selectively focus on relevant segments of input sequences, thereby significantly improving their capability to interpret and generate structured textual data. Although initially designed for NLP tasks, Transformer-based models have found applications in cybersecurity, providing advanced solutions for monitoring sequential data streams, modeling normal system behavior, and detecting anomalous or malicious patterns. Consequently, this has expanded the attack surface, increasing vulnerabilities such as unauthorized access, malware propagation, zero-day exploits, data breaches, denial-of-service (DoS) attacks, social engineering, phishing, and other cyber threats, resulting in substantial financial and operational losses for organizations and individuals.
However, deploying large-scale generative AI models in edge-cloud computing environments—such as smart cities, Industrial IoT (IIoT), and autonomous vehicle networks—faces significant challenges. These environments demand dynamic, collaborative, and real-time cybersecurity solutions to effectively safeguard edge devices and endpoints.
Objectives
This dissertation aims to explore and implement computational offloading strategies to develop compact yet effective generative AI models for intrusion detection, employing techniques such as model compression, model partitioning, and knowledge distillation.
Innovation
The application of computational offloading methods to reduce the computational complexity and resource footprint of generative AI-based intrusion detection models, while maintaining their accuracy and real-time detection capabilities, represents a novel and impactful contribution to cybersecurity research.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Computer science
The compliant algorithm adapts itself to existing data structures; the non-compliant one persists in modifying data structures to fit its own architecture. Therefore, all computational progress depends on the non-compliant algorithm.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit its target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Machine learning - detected
Attention is all you need
Comedy
Timing is all you need.
3 months ago
Machine learning - detected
Attention is all you need
Economics
Incentives are all you need.
3 months ago
Machine learning - detected
Attention is all you need
Physics
Interaction is all you need.
3 months ago
Machine learning - detected
Attention is all you need
Developmental biology
Morphogen gradients are all you need.
3 months ago
Machine learning - detected
Attention is all your need
Comedy
Timing is all you need.
3 months ago
Machine learning - detected
Attention is all your need
Economics
Incentives are all you need.
3 months ago
Machine learning - detected
Attention is all your need
Cell signaling
Selective receptor activation is sufficient for cellular response.
3 months ago
Machine learning - detected
Attention is all your need
Developmental biology
Competence is all you need.
3 months ago
Machine learning - detected
Attention is all you need
Cell signaling
Signal specificity is all you need.
3 months ago
Machine learning - detected
Attention is all you need
Physics
Interaction is all you need.
3 months ago
Machine learning - detected
Attention is all you need
Chemistry
Catalysis is all you need.
3 months ago
Machine learning - detected
Attention is all you need
Economics
Incentives are all you need.
3 months ago
Machine learning - detected
Attention is all you need
Developmental biology
Morphogen gradients are all you need.
3 months ago
Computer Science - detected
Attention is all you need
Developmental biology
Morphogenetic signaling is all you need.
3 months ago
Large language models - detected
Attention is all you need
Economics
Incentives are all you need.
3 months ago
Computer Science - Artificial Intelligence - detected
Attention is all you need
Comedy
Timing is all you need.
3 months ago
Computer Science - Artificial Intelligence - detected
Attention is all you need
Psychology
Selective attention is all you need.
3 months ago
Computer Science - detected
Attention is all you need
Physics
Interaction is all you need.
3 months ago
Computer Science - detected
Attention is all you need
Developmental biology
Morphogen gradients are all you need.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Computer Science - Artificial Intelligence - detected
Attention is all you need
Developmental biology
Morphogenetic signaling is all you need.
3 months ago
Computer Science - detected
Attention is all you need
Cell signaling
Signal amplification is all you need.
3 months ago
Computer Science - detected
Attention is all you need
Olfaction and behavior
Selective odorant perception is sufficient for behavioral response.
3 months ago
Computer Science - detected
Attention is all you need
Computer science
Attention is all you need
3 months ago
Computer Science - detected
Attention is all you need
Neuroscience
Neuromodulation is all you need.
3 months ago
Computer Science - detected
Attention is all you need
Economics
Incentives are all you need.
3 months ago
Computer Science - detected
Attention is all you need
Olfaction and behavior
Selective odorant perception is sufficient for behavioral response.
3 months ago
Computer Science - detected
Attention is all you need
Physics
Interaction is all you need.
3 months ago
Computer Science - detected
Attention is all you need
Developmental biology
Morphogenetic signaling is all you need.
3 months ago
Biotechnology - detected
We don’t want to try to tell every cell and every gene what to do. We’re not looking to teach cells how to grow a leg; we’re looking to convince them that that’s what they should do.
Psychology
We don’t want to try to dictate every thought and every behavior. We’re not looking to teach individuals how to achieve a goal; we’re looking to persuade them that that’s what they should pursue.
3 months ago
Biotechnology - detected
We don’t want to try to tell every cell and every gene what to do. We’re not looking to teach cells how to grow a leg; we’re looking to convince them that that’s what they should do.
Developmental biology
We don’t want to try to instruct every cell and every gene on their specific roles. We’re not aiming to teach cells how to form a limb; we’re aiming to persuade them that this is the target morphology they should achieve.
3 months ago
Computer Science - detected
Attention is all you need
Comedy
Laughter is all you need
3 months ago
Computer Science - detected
Attention is all you need
Developmental biology
Morphogenetic signaling is all you need
3 months ago
Computer Science - detected
Attention is all you need
Computer science
Computation is all you need
3 months ago
Computer Science - detected
Attention is all you need
Neuroscience
Neural attention mechanisms are all you need.
3 months ago
Computer Science - detected
Attention is all you need
Economics
Market signals are all you need
3 months ago
Computer Science - detected
Attention is all you need
Developmental biology
Morphogenetic signaling is all you need
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Physics
The compliant particle conforms to the forces of the universe; the noncompliant one persists in trying to alter the forces to suit its own state. Therefore, all advancement in physics hinges on the noncompliant particle.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Economics
The rational investor adapts themselves to the market; the contrarian persists in trying to influence the market to their advantage. Therefore, all innovation depends on the contrarian.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about pattern memory content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue patches (that comprise a cellular ensemble) and reconstructing information flow between patches. Stable bioelectric fields can allow latent states to be transferred between body areas, in accord with modern morphogenetic theory.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue patches (that comprise a cellular ensemble) and reconstructing information flow between patches. Stable bioelectric fields can allow latent states to be transferred between body areas, in accord with modern morphogenetic memory theory.
3 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Economics
It is known that the exact firms maintaining a given market position (the economic ensemble) change from period to period. This raises the question of how the economy achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the financial flows that arise from economic activity. We show that financial flows carry information about market dynamics. The financial flows, in turn, can act as "guard rails" that funnel higher dimensional variable economic activity along stable lower dimensional routes. We obtained the latent space associated with each market position. We then confirmed the stability of the financial flow by mapping the latent space to different market sectors (that comprise an economic ensemble) and reconstructing information flow between sectors. Stable financial flows can allow latent states to be transferred between economic areas, in accord with modern market theory.
3 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about pattern memory content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue patches (that comprise a cellular ensemble) and reconstructing information flow between patches. Stable bioelectric fields can allow latent states to be transferred between body areas, in accord with modern morphogenetic theory.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Philosophy - detected
What's your p(doom)
Computer science
What's your p(system failure)
3 months ago
Philosophy - detected
What's your p(doom)
Cell signaling
What are the probabilities of pathway failure?
3 months ago
Philosophy - detected
What's your p(doom)
Developmental biology
What's your p(malformation)
3 months ago
Philosophy - detected
What's your p(doom)
Economics
What's your probability of market collapse?
3 months ago
Philosophy - detected
What's your p(doom)
Psychology
What's your probability of experiencing existential dread?
3 months ago
Culinary Arts - detected
Cup of coffee at a nice cafe
Psychology
A moment of mindfulness in a pleasant environment.
3 months ago
Unknown - detected
Cup of coffee
Psychology
Motivational stimulus
3 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue patches (that comprise a cellular ensemble) and reconstructing information flow between patches. Stable bioelectric fields can allow latent states to be transferred between body areas, in accord with modern morphogenetic theory.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit its target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Comedy
The straight man adjusts to the punchline; the clown insists on bending the punchline to fit his own joke. Therefore, all comedy gold relies on the clown.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Physics
The compliant particle conforms to the field; the noncompliant one persists in trying to alter the field to suit its own state. Therefore, all advancement in physics hinges on the noncompliant particle.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Computer science
The adaptable algorithm optimizes itself to the environment; the disruptive one persists in trying to optimize the environment to its parameters. Therefore, all innovation depends on the disruptive algorithm.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about pattern memory content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue patches (that comprise a cellular ensemble) and reconstructing information flow between patches. Stable bioelectric fields can allow latent states to be transferred between body areas, in accord with modern morphogenetic theory.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Unknown - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the body achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about pattern memory content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent space associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent space to different tissue patches (that comprise a cellular ensemble) and reconstructing information flow between patches. Stable bioelectric fields can allow latent states to be transferred between body areas, in accord with modern morphogenetic theory.
3 months ago
Philosophy - detected
The reasonable person adapts themselves to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable person.
Developmental biology
The receptive cell attunes itself to the morphospace; the uncompromising one persists in trying to modulate the morphospace to fit the correct target morphology. Therefore, all advancement in morphogenesis hinges on the uncompromising cell.
3 months ago
Neuroscience - detected
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.
Developmental biology
It is known that the exact cells maintaining a given pattern memory (the cellular ensemble) change from trial to trial. This raises the question of how the developing organism achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the bioelectric fields that arise from cellular activity. We show that bioelectric fields carry information about morphogenetic pattern content. The bioelectric fields, in turn, can act as "guard rails" that funnel higher dimensional variable cellular activity along stable lower dimensional routes. We obtained the latent morphospace associated with each pattern memory. We then confirmed the stability of the bioelectric field by mapping the latent morphospace to different tissue regions (that comprise a cellular ensemble) and reconstructing information flow between regions. Stable bioelectric fields can allow latent states to be transferred between body areas, in accord with modern morphogenetic field theory.
3 months ago